Wrensong - do you mind me asking which HRT you currently take?? I was advised Angeliq/Testogel works well. I read Nick Panney and other consultants like this combined HRT.
Also when will I start to see improvements and do you think too high Thyroxine has affected my heart?? as I have been having palps the last 2 weeks.
Warwick - I am on Evorel Conti patches which have helped to some extent, but haven't got rid of all symptoms & trials of other HRT combos have so far made things worse. Had heard that transdermal methods are less likely to interfere with thyroid meds, but have still had to adjust my T4/T3 several times since starting HRT, especially when Sandrena gel was added for a while, then discontinued. Endocrinologist agreed even transdermal HRT can alter thyroid status.
Oh dear - wish I knew enough to give reliable answers to your other questions, but can only speak from my own experience I'm afraid. If you mean how soon to see improvements in possible symptoms of too much Thyroxine, I really don't know, but when I was on Thyroxine alone (ie no T3, no HRT), I could usually feel a difference in major thyroid symptoms around 7-8 days after reducing/increasing Thyroxine.
If you mean how soon to see changes in meno symptoms as a result of the Angeliq - I think I could feel a difference after about a month of first starting Evorel, but it wasn't dramatic - hard to remember now, as around 21 months ago. Like yours, my oestradiol was below the bottom of the ref range when tested post-meno (but before HRT - not retested since) & they suspect I don't absorb well from patches which may explain why the response wasn't dramatic & why I still have residual symptoms.
Hopefully any anxiety, jittery tummy, hyper-type symptoms will reduce for you quickly, though I know from the forum that HRT can cause these symptoms in some ladies too. Goodness, it's all so confusing isn't it & so hard to unravel everything when thyroid conditions & meno are combined? With having had to reduce Thyroxine shortly after starting the Angeliq, I think this could make it more difficult for you to know which changes are due to which meds. You will already be very used to being patient with HRT changes & it's a right pain, I know.
I wouldn't think having had too much Thyroxine for just a short while will have had a lasting effect on your heart, but please do get in touch with your GP if you are worried as they are the best to ask. As you know, palpitations can result from too much Thyroxine & in my experience too little, as well! We also seem to be especially prone to them during the meno process & I have had a return of these very recently during a now abandoned trial of a different HRT regime, so for me they can be caused by gynae hormone fluctuations as well. My GP wanted to listen to my heart & gave me a quick ECG to check the palps out again & this was all fine - for me they are due to harmless ectopics, though when they come in long, persistent bouts & feel irregular it can be scary, I know.
I find that each change of meds, whether thyroid or HRT can really upset the apple cart and take a toll on the body, but if you can get as much relaxation as possible, try to divert worries by doing whatever feels good for you & focus on the thought the latest meds changes could make you feel so much better, I hope this will help you get through the adjustment phase & quickly too. Good luck with it - I will be thinking of you & willing it all to go well.