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Author Topic: Patch adhesive irritation  (Read 3097 times)

Charski

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Patch adhesive irritation
« on: December 02, 2016, 02:43:04 PM »

Hi all

I had my early menopause confirmed at 41 after many years of undiagnosed peri symptoms, by which point my FSH was over 80. Thanks to browsing the advice on this brilliant forum I asked for bioidentical HRT and am on Estrodot 50mcg with Utrogestan 100mg on days 15-25. Also Sertraline 50mg daily but that's another story...

Unfortunately my sensitive skin has let me down and I'm now experiencing intense skin irritation from the adhesive in the patches. It's causing tiny blisters under the skin, itching and redness.

Has anyone else experienced this and switched to using a different mode of oestrogen delivery?

After 15 months on HRT it's having a mild effect I guess but nothing dramatic, with some unpredictable cycles (perhaps as my body tries to return to menstrual function after going through and beyond meno on its own?). Not sure how much of the depression I've had recently is hormonally linked - suspect a significant element - I have found it a pretty miserable time really.

Any advice on how I can improve my quality of life?  Is it worth me investing in a consultation with Prof Studd or similar?

Thanks for any help you wonderful women can give.  :thankyou:
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Annie0710

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Re: Patch adhesive irritation
« Reply #1 on: December 02, 2016, 02:55:49 PM »

That's sad, I have very sensitive skin and allergies, even trying on clothes some days can leave marks on me but I'm fine on estradot, I get minimal redness when I take a patch off

Have you tried an oestrogen gel ? Oestrogel is quite popular here and I think an advantage would be you could increase /decrease the dose easily

Did you have depression/anxiety generally before hormones were involved ? If not very likely hormone induced which tweaking your oestrogen dose may help

Other more knowledgeable members will be along soon I'm sure

X
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Tinkerbell

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Re: Patch adhesive irritation
« Reply #2 on: December 02, 2016, 02:59:02 PM »

I couldn't tolerate the adhesive on Estradot patches even though they are very small...one doctor suggested I changed to Evorel patches but as they are larger I declined her suggestion.
I switched to Estrogel,so much better!
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Hurdity

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Re: Patch adhesive irritation
« Reply #3 on: December 02, 2016, 03:08:56 PM »

Hi there Charski

 :welcomemm:

I have used Estradot patches for years without problems. However I was worried initially about possible irritation as I have sensitive skin and at first I could feel itchiness developing. I made sure that I never ever scratched on or near the patch site even if it was itchy and in particular always peeled off the old patch very very slowly (never ever rip it off) - as you do with a plaster so there could be no reaction due to this.

Also alternate right and left side wherever you put it and don;'t use the same skin site for a while. If this isn't working and you get the reaction every time despite being that careful then either a different patch ( although all the othere are huge by comparison!) - or perhaps change to gel - Sandrena or estrogel.

These are all available on NHS as with Estradot.

You will find plenty of women have swapped from one to the other for various reasons so hopefully they will share their experiences.

How regular were your periods when you started HRT? If you were in the peri-menopausal transition - skipping periods and perhaps going 3 months or more without one, then you could be quite advanced and that oestrogen dose is far too low for someone of your age! This could explain your low mood. I would look to increasing it (gradually if you are sensitive to changes) but personally at your age I would want to be on 100 mcg patch - so gel might be better if your allergy persists?

Did you suffer from depression at other times in your life or due to life circumstances or do you feel it is hormonally related? Certainly increasing oestrogen is the first thing you can do to improve mood.

How do you feel physically apart from that - eg libido, muscle aches etc? It is possible you may have low testosterone but that tends to be less related to menopause than actual age unless ovaries have been removed.

I would try some of these suggestions first through existing channels and if necessary ask to be referred to a menopause clinic through NHS. No need to have an expensive private consultation with Prof Studd. He tends to prescribe much the same to all women (from what is reported on here) ie between 2 and 4 pumps of estrogel, cyclical Progesterone ( 7-10 days) and testosterone gel.  The only thing you may not be able to get on NHS is the T - if it is even necessary in your case - although several women are having success with this now (ie getting it prescribed).

Quality of life? I am sure you will be aware that exercise, fresh air, diet, body weight reducing stress, stopping smoking. reducing alcohol are all measures you can take to help your general health and walking and the outdoors especially can improve feeling of well-being. Are there areas of your life perhaps that you can change so that things are less stressful - if they are now?

Just a few random thoughts which might help :)

Hurdity x
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Charski

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Re: Patch adhesive irritation
« Reply #4 on: December 02, 2016, 03:13:28 PM »

Thanks Annie and Tinkerbell, it's really helpful to have your insight...and interesting to know that you've also experienced adhesive sensitivity with Estradot Tinkerbell. Annoying because they are so discreet I really want to get on with them - I was prescribed Estraderm patches originally (I guess they are cheaper?) but felt like I'd stuck half a carrier bag to my butt with all the rustling around.  Not cool ;)

I'm pretty sure my depression/anxiety started when my hormones first went haywire, which was about 18 months after my twin pregnancy. They're 11 now so I've not been myself for such a long time...

Sounds like Estrogel is worth a try so I will visit my GP, but he doesn't have a particular specialism in women's health so has to remind himself of HRT protocol every time I see him  :-\
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Charski

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Re: Patch adhesive irritation
« Reply #5 on: December 02, 2016, 03:24:39 PM »

Hurdity, that is enormously helpful, thanks a million for your reply.

I did go back to my GP about 6 months ago (after 8 months of HRT) saying that I felt I needed to up the oestrogen, as I still had many of the original post-meno symptoms. But because the 50mg had stopped the flushing, he felt that it was sufficient and that my low mood and libido, muscle aches, fatigue etc were actually down to depression so I started the ADs.

I'm very lucky to have a lovely family and a job I enjoy, so I have always felt that my low mood is hormonally linked. I know I should look after myself but it's such a battle to eat properly and exercise when I have no motivation and my self esteem has been shot to bits by the menopause.

Sorry for the self-pitying post. I am usually an upbeat, positive person but sometimes this menopause **** gets me down.

I genuinely appreciate your insight and advice, and will get back to my GP asap. Is there any clinical evidence/protocols I can look at for levels of oestrogen therapy and the case for testosterone replacement for women diagnosed with POF?

Thanks again
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Charski

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Re: Patch adhesive irritation
« Reply #6 on: December 02, 2016, 03:30:04 PM »

Forgot to answer your question Hurdity about period frequency before HRT started; I first went to the GP when I realised I hadn't had a period for the best part of a year. They had been really erratic before then too, a combination of no period for a couple of months then a bleed every two weeks. Exhausting! I just had the one blood test for FSH but with a level of 83 the GP told me my body was 'flooded' with it. Still not sure just how high that was in comparison to the norm but he was pretty convinced I was menopausal if not post-menopausal.
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Hurdity

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Re: Patch adhesive irritation
« Reply #7 on: December 02, 2016, 04:08:16 PM »

You should definitely be on a much higher dose of oestrogen at your age!!! Think of what you would be producing had you not gone through menopause so young.

Yet another example of a doc prescribing ADs when they shouldn't, through ignorance! He should know that flushes and sweats are not the only indication of sufficient hRT - maybe OK for someone in late 50's - who maybe doesn't want to take a very high dose ( because of having to take a lot of progesterone). The dose required to eliminate flushes and sweats is the MINIMUM  dose which should be used. This may not equate at all with ideal feelings of well-being and mood. I know I would probably feel much better with a higher dose - but I've left it too late now and as I was OK on the dose I started at (50mcg) - I presumed this was all I could expect. Now in my early 60's I have increased slightly to 62.5 mcg which is higher than you at your very young age!

Please go back to your GP or find another in the practice that specialises in menopause - or if he is willing to work with you ask for an increase in dose/change to gel asap!!

Have a look at the recommendations in the NICE Guidelines on menopause: go to home page of the website and scroll down for all the links:
http://www.menopausematters.co.uk/index.php

There is information about POF on there too although not specific dosage. The T replacement is recognised as a possiblity for those with low libido but an increase in oestrogen alone should help with this. What are your bleeds like on your current regime and do you take utrogestan orally?

FSH levels cannot determine whether you are post-menopausal - as they vary so much through the peri-menopausal transition - here is the section on diagnosis and FSH: http://www.menopausematters.co.uk/diagnose.php

There is also some information on POF too:
http://www.menopausematters.co.uk/pm-definition.php
http://www.menopausematters.co.uk/pm-management.php

Hope this helps and hot foot it to your doc preferably one that does specialise in women's health! Hopefully if you get the HRT right you will be able to come off the ADs as these are not supposed to be prescribed for hormonal anxiety/depression - it is important to get this right first!!

Hurdity x



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Charski

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Re: Patch adhesive irritation
« Reply #8 on: December 02, 2016, 04:51:26 PM »

I can't thank you enough. You have articulated the thoughts I'd dismissed about dosage and relationship to depression. I'll look at all the links you've provided and will go back to my GP - if no joy there I'll switch to a different practice as I don't think they have a menopause specialist. I'll be happier standing my ground as long as I have the right info to justify an increased dosage, so you have all helped me enormously.

My bleeds are still generally light and brief - maybe one heavier day then petering out to nothing over the following 48 hours. And despite the HRT regime they are still unpredictable as to when they start in the month. I do take the progesterone orally - 2 tablets at night for 10 days from day 15.

And most of all thank you for saying I'm very young! I feel like such a wizening crone around my contemporaries that you have given me a great boost   :)
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