Mis71Mum, Is this your first time trying hrt? I apologize if I missed that, my brain is skittery today. I ask because I recall reading a website where a doctor said he observed a pattern in the improvement in his patients. Something like the first couple weeks he attributed the positive difference to placebo effect, then there is an up and down period, and maybe after the first 2 months everything levels out and the improvement can really be seen, or it becomes clear that it isn't enough. I may have the time frames a little off, and I'm sorry I don't have a link for it. But hopefully you get the general idea. I would follow the low dosing these other ladies have advised and give it several weeks to stabilize, even if you have some blips along the way. Crossing my fingers that it's easy going for you!