I took Angeliq for two months and was a complete mess. Cystic acne, depression, low energy, anxiety. As soon as i stopped, i started to feel better, though for weeks i had to deal with unsightly scars left by those cysts once they were reabsorbed. Definitely intolerant to progesterone. Then i switched to estrogel+utrogestan (i take utrogestan vaginally for 10 days a month) I am not happy with the progesterone phase but cannot avoid taking it. No acne on utrogestan, but after a few days the depression comes back, and i become antisocial. I just want to hide! I lose interest in my usual activities, my energy levels plummet, my muscles ache as if i had flu, working out becomes almost impossible, i just want to curl up in bed with a book and a cup of tea. It's like being sick for a week a month.