Hi, yes on vagifem, but i was so raw and imflammed for some reason, that i could feel the tablet up there, chaffing me as i walked.. but i have persevered, im hoping as i seem to have good days and bad days, that its one of those things that gradually improve over times, as the nerves settle. i guess thats why i was given the amitripyline.. Although i can still feel discomfort while im taking it, i dont want to increase the strength. but im feeling more comfortable gradually. But im curious if i missed a dose, how much pain i would be in.. but to chicken to give it a try.. but tempted.. going back to the time this started, i was using vagifem and this swelling and pain occurred, im still non the wiser why it happened.. all i can say is when i tried canasten to see if it was a thrush infection, that burnt like hell, that probably increased the imflammation and irritation.. so now if i think i might have thrush i will get the tablet.. iv never been that keen on taking tablets, so preferred the vaginal route, which i have used before no trouble at all.. doctors tend to treat for thrush here over the phone, oh you might have thrush, here get some tablets, oh you might have bv here takes some tablets.. without seeing you .. im not a fan of it .. i would like to be seen.. anyway non the less i feel like im improving, but got a long way to go, as its far from settled.. im hoping the vagifem will settle things eventually.. but i do have sensitive skin in general, my hands break out with liquid hand wash, and my skin has got thin. so maybe up there has been deteriorated up there as well. thank you for your comments and replies. i felt like someone was listening and helping,. thank you xxx