Hi, thank you for all your replies, its reassuring to know that there are a few over 60s who have been using vagifem or ortho gynest, for a long period.. up to their 60s, like myself. what are the pros and cons do we all think off vagifem or ortho gynest.. it seems some of us have at some point had unsettled periods on vagifem from time to time. maybe we miss peanut oil base that the ortho gynest has, that would make the hormone last longer. heres another query, why have they dropped vagifem to two 10mcg the recommended dose a week , when the estring is 7.5mcg a day ... i myself have been on some sort of vaginal hrt since 2003 .. although i did see a gyne who said i was cured lol.. mmmmmmmm.. if we could all review a product i.e. as products are on amazon, would vagifem get the most positive reviews i wonder lol.. what do you think... or is there really a marvelous moisturiser out there waiting for us all..