Hi ladies, Wow, I can really relate to so many of you here. I'm 46 and had a total hysterectomy just over two years ago. I'm on 2mg Kliofem HRT and 9 months in I suffered the worst anxiety ever. I couldn't go out of the house, in the occasions I did - once I had to abandon a trolley in the supermarket and flee, another I drove to a shopping centre car park and sat there crying as I couldn't get out of the car. ADs helped and I came off them a year later. I've been fine since but anxiety is always lurking and is starting to come back more now. To the person who mentioned pulling out of social situations, that's me too. I feel I've become very selfish in that I only do what I feel I can do rather than follow my friends into situations I may not be able to cope in. Also, my ten year relationship broke down last year for reasons on both sides but my part is that I need to be by myself rather than with someone who just doesn't understand how I'm feeling (we are still very good friends). I've taken up running but need to do that, or walk, more. I've started to wean myself off HRT in favour of natural methods and will see how that goes. Having found your posts almost makes me feel normal. We will get through this.