I was on my third HRT regime, which I had researched (this site and many more!) I had to give up the previous two due to bad headaches. I believed, again by research, that it was the progesterone causing these (I had suffered badly from PMT before my menopause) so was looking to try bio identical.
I chose to ask for Utrogestan 100mg and Estrodot 25mg. I had been on it for about 6 weeks? when I came across a website extolling the virtues of Progesterone only HRT. I was a tad cynical, as they also sold the product, but read all I could because I was still getting vague headaches (although it may not have been due to the HRT) and weight gain, which almost certainly was!!
I also have Graves and felt the oestrogen (an anti thyroid, for want of the scientific term!) was making me more hypo.
According to the website, if your Vitamin D levels are too low (and some other things, you would need to read through) and the amount of progesterone you are taking, too low, you will have symptoms of Oestrogen dominance.
Anyhoo, two weeks ago I stopped using the Estrodot and starting opening up the Utrogestan capsule and rubbing it into my skin, changing area each night. I have had no flushes which I get within two/three days of stopping oestrogen. I don't feel as tired, but that may be that no oestrogen means I'm less hypo thyroid. I haven't lost weight, but neither have I put anymore on. Sleep is a bit erratic, one night ok the next not so good, but again I think that has to do with my Graves and being less hypo (I was sleeping every night like a stone, 10/12 hours, but not feeling the least refreshed in the morning)
So, I will try this for minimum 3 months unless I get any weird side effects.