Hello, I have been using Oestrogel for the past week. It is the 8th day on it and I feel better today. I was suffering from so many symptoms for so long, vaginal atrophy, blood in the urine, lack of libido, depression, moods, irritable, only sleeping for a couple of hours. I was always exercising every day, running and swimming. To be honest that never helped me to feel better. Also I have tried so many vitamins. My mother had breast cancer. The doctor did offer antidepressants, but they wouldn't have helped the physical problems. Just have to see how it goes.