I had been given Gynest about a year ago, before I started full HRT.
I had raised concerns with my GP about side effects, but she said the level of hormone
was so small (0.001%) side effects would be very unlikely.
The actual thing I had raised with my GP was "will this stuff give my OH boobs?" He was worried, bless him.
When she stopped laughing, which took some time, she managed to say the dose of hormone was very very tiny,
so OH would not need to buy a bra....
The only issue I had with the cream was it was a bit messy, got everywhere.
However it did help a bit with dryness issues