For about a year when I first started to use Vagifem 2 a week was enough to keep me perfect. Then I guess I must have taken a big drop in my own oestrogen, had a lot of discomfort again, used one a day for nearly 3 weeks then 4 a week, then cut down to one every other day. Had 2 or 3 'blips' since then but thankfully have have come good after using one a day for a while. Hope that will happen this time. Don't want to use more than I need, but have to be comfortable. Am concerned about possible future risk, but got to have quality of life now. As you say, everyone is different and GPs should be willing to prescribe what is needed, as long as they have warned the patient about possible risk. The decision should be up to the patient if they have all the relevant information. May have said this before, but if I get something on the 'risk' list, I won't know if its because I used this medication, or whether I would have got it anyway. xx