I was using vagifem, and the GP said twice weekly, after the initial 3 weeks of every night. Then it didn’t seem to be as good, and I had terrible cystitis symptoms (no bug in the urine though) had 2 lots of antibiotics which did nothing, so I changed to Ovestin. The problem is I did the initial loading of every night, and now on 2 x weekly and the bladder pain comes back. I spoke to a private GP (part of my health care) and he said use it every night (‘it won’t do you any harm’) I’m 71 and it’s the recurring ‘cystitis’ that is awful. Does anyone else use vaginal estrogen every night?