Hi, I was on Livial (Tibolone) a couple of years ago for about a year. I would say it took about a month to start seeing some benefits and more so by three months. There were some negative mood effects during that first month, but this changed after that to be more positive, increased motivation, energy, libido etc. It did not help very well with night time flushes. I switched to patch for a year but I am now having a go back on Livial (Tibolone). The consultant has just suggested I try doubling the dose (5mg) to see if that helps to combat all symptoms - it has only been a few days so I can't comment yet. I would say give it up to 3 months to see whether it suits you or not. Good luck.