I'm interested to hear if anyone has experienced similar side effects to mine whilst using Utrogestan 100 capsules. I first took Utrogestan 100 orally and although I felt okay physically, my mood plummeted rapidly and I felt so depressed that I had to stop taking it. On advice from my menopause consultant I tried the vaginal method last month for 10 days. I had heavy bleeding as expected and experienced quite a high whilst using it. However towards the end of the 10 day course my hair turned to straw, my nails went brittle and broke off and I had sore breasts. Once I'd finished the course my mood deteriorated again and I felt tearful and very low. I feel that the Utrogestan remained in my system for approximately 3 weeks after discontinuing the capsules - much longer than others have reported and it's only been this last week that I've felt back to normal. I expected some side effects but my experience has put me off using them again. Perhaps the side effects lessen the more you use it, although if I only use it every 3 months would my system never get used to it? My consultant recommends that I have a scan soon to determine the thickness of my lining and to continue using Utrogetan vaginally on alternate days for 10 days every 3 months. I expect that I would also need regular scans anyway due limited progesterone usage. I use Evorel 75 patches which seem to suit me perfectly, together with Testim gel, which I also limit. I have tried Evorel Conti and it didn't have any adverse effects but would much rather use the bioidentical progesterone/Utrogestan. I wonder if I should reduce my patches to 50 or even lower to balance the low dose of progesterone, which I have done before on various occasions without any problems but as I'm about 4 years post menopausal, feel that the higher 75 dose may be better for future-proofing against osteoporosis etc. I am aware that some people believe that lower doses may be just as effective however. Any advice would be much appreciated!