I have now read on here that Evorel can cause depression and headaches. I wish I had read that years ago. Although the break up of my marriage was for other reasons, it certainly made the aftermath more painful as I had mood plunges that made me very unhappy. Fortunately, not being prone to depression I knew I would feel better soon, so disregarded them. But I may have had a happier and more productive few years, with less headaches, if I had known that Evorel has this effect. Looking forward to going back on FemSeven which gave me no such symptoms. Femoston Sequi give me headaches too but my mood was fine for the short period I was on them.