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Menopause Matters magazine ISSUE 81 out now. (Autumn issue, September 2025)

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Author Topic: Evorel Sequi patches  (Read 36106 times)

bev567901

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Re: Evorel Sequi patches
« Reply #15 on: May 07, 2014, 02:24:04 PM »

Thanks Honeyb, I am hoping someone else might search for Evorel Sequi as we all do that awful worried looking thing. I think HRT will help me to help myself,  I think that about most medication. B x
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bev567901

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Re: Evorel Sequi patches
« Reply #16 on: May 30, 2014, 08:51:41 PM »

Next Evorel Sequi update for anyone searching......I have come to the conclusion that I feel better on the Conti part compared to the 50 part. This contradicts everything else I read whereby ladies felt anxious & down. This has led me to believe maybe I need more progesterone & possibly I have too much estrogen going on which would match the fact that nausea has been my worst peri symptom. I am going to look into ways naturally via food or supplements first before adding anything else as I would like to do a 6-7 mth trial first on this HRT.
My period cramps are far worse than pre HRT & the bleeding is heavier. The fact I know what day it is coming now cancels this out for me but I am going to find some better pain relief for a couple of days a month. I am happy on these patches so far, my workload is through the roof & I am coping. I did think earlier on today with it being the 2 weeks half term school holidays, I am fully work booked up, all the daily stuff to do and my youngest daughter being sick as I rushed about how would I have coped 10 mths ago? Probably not very well so 😄😄 B x
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Suzyq

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Re: Evorel Sequi patches
« Reply #17 on: May 31, 2014, 01:32:54 AM »

Great news!
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Milamam

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Re: Evorel Sequi patches
« Reply #18 on: May 31, 2014, 06:02:17 AM »

Hi Bev,
Really great news that you've found what works for you!!! Hang in there and keep us updated! So helpful to know that probably my nausea in the past three days or so is perhaps due to higher estrogen (compared to progesterone). Fingers crossed things will continue to be upward for you!
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bev567901

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Re: Evorel Sequi patches
« Reply #19 on: May 31, 2014, 10:29:39 AM »

Yes it is, just fathoming it out slowly but surely & not doing anything rash. I wasted a whole year pre HRT so what is another one  ;D  I think my estrogen may always have been high going on my symptoms every month all my adult life so in peri its gone off the scale. Patience seems to be the key & not expecting miracles. I just know it will come right in the end, it has to  ;) B x
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Hurdity

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Re: Evorel Sequi patches
« Reply #20 on: May 31, 2014, 11:26:59 AM »

Hi again bev

I am assuming you are feeling rough on the 50 part due to the pms just before your period and then feeling bad during your period? This is only to expected and is annoying isn't it - that we continue our cycle artificially and therefore have to continue with pms and periods and all that entails.

Just to clarify - it is unlikely that your symptoms are to do with high oestrogen though (well the pms ones anyway) - if you have been having bad monthly pms all your adult life this will be due to either: progesterone intolerance ( progesterone increases rapidly following ovulation), the withdrawal experienced by sudden drop in progesterone just before the period ( this is a phyisiological response), or drop in oestrogen which also occurs throughout the second half of the cycle. Most women feel at their best following their period and up to, and just after the middle of the month when oestrogen is at its highest!

Added oestrogen is usually a constant dose when you take HRT - any fluctuations are most likely due to your own hormones. If you can also tolerate the progestogen, then you may well notice the negative effects of withdrawal after you change to the oestrogen only patch. This isn't due to the oestrogen, but as I said above, a physiological response to the drop in progestogen - which is what most women experience just before a period.  Most women feel at thier best once the progestogen has cleared from their system. and they are taking oestrogen only ( just as in their natural cycle). Unfortunately with HRT, the time between the end of the period on oestrogen only, and starting the progestogen part may only be a few days so some women only feel good for 7 days in the month!

bev - you do not need more progestogen in terms of symptoms! The amount you take is calculated to oppose the oestrogen's effect on the womb lining, and to ensure it does not thicken. For most women the dose ensures this is effective. You would need extra only if your lining has thickened.

It may well be that while you are still peri, your own oestrogen surges, combined with the added oestrogen from HRT, sometimes leads to side effects - but unfortunately there is nothing that can be done about this I don't think - and is another disadvantage of taking HRT early in peri while periods are fairly regular - you will never now when your own hormones are going to rise suddenly.

Hurdity x
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Milamam

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Re: Evorel Sequi patches
« Reply #21 on: May 31, 2014, 12:21:22 PM »

Hi Hurdity,
I haven't seen a better explanation of what is going on even though in the past couple of days I was realy trying to figure it out all. Thank you!!! When I started HRT my bloodwork showed low estrogen, normal progesterone, relatively high FSH but not off limits, and AMH and B inhibin below limits. These last two indicate low or absent ovarian reserves. So it makes sense that now on HRT I will still have disturbances due to my own hormonal fluctuations during the month buy these disturbances should decrease in strenght, right? (My weird logic sometimes fools me). It is true that I felt at best in the 3rd week of the cycle, I wish I felt like that throughout!

And last question - should I then discuss with the Dr. To change to a gel so that I can perhaps regulate the estrogen levels as symptoms indicate? or ask to do less progesterone during the cycle? I know this is not possible with the current HRT I am on (Femoston 2/10) so this might mean changing ?

Thank you again so much!!!
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Suzyq

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Re: Evorel Sequi patches
« Reply #22 on: May 31, 2014, 07:50:34 PM »

Hurdity is undoubtedly knowledgeable, but this explanation doesn't fit my experience! I feel much better on progesterone and now am taking it daily feel more level, very little anxiety! Even accounting for the rises and falls in progesterone levels, I felt pretty crappy on estrogen only part and for years my estrogen levels were fairly high but I suffered tremendously from low progesterone. Physiologically progesterone may oppose estrogens actions on the lining of the womb but it has many other benefits. Just as living with zero estrogen is difficult, so is it living with zero progesterone! Everyone is different so the key is to find a balance that works for you!
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Hurdity

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Re: Evorel Sequi patches
« Reply #23 on: June 01, 2014, 09:08:44 PM »

Hi Milamam

I can't really advise on what would be best for you - it is a question of trial and error really. I would say though that a transdermal method should give you a more consistent dose of oestrogen than tablet HRT where most is lost through the metabolic process.

Also it's difficult to compare the effects of added HRT with endogenous hormones (ie the ones produced by our own bodies during our natural cycle) - and I think HRT is only doing this crudely. I don't think either, that symptoms will respond instantaneously to changes in gel dosage ( although they seem to for a few women). You would not know in advance what your own hormones are doing so for example you might anticipate a hormonal surge in oestrogen, and reduce the gel dosage - but the surge may not happen so you could end up feeling worse.

What is surprising, is that almost no HRT regimes recreate the rise and fall of the natural oestrogen cycle but average it out over the whole cycle ie you have a constant dose. I think this is to avoid the lows (in oestrogen and mood) experienced pre-menstrually - but I don't know though.

Re progesterone - as I explained you need to have a certain amount to oppose the oestrogen's effect on the womb lining. With the "separates" combo - ie oestrogen patch and separate (micronised) progesterone - Utrogestan - it is possible to vary the amounts of reach hormone independently - although best to do this under medical supervision since any reduction in the licensed dose of progesterone compared to oestrogen - needs closer monitoring to ensure the lining doesn't overthicken.

If you are progesterone intolerant and your GP doesn't cooperate, then maybe you could be asked to be refered to a menopause clinic if there is one in your area?

Suzyq -we do continue to make progesterone and oestrogen during post-menopause. From what I've read post-menopausal progesterone is generally at the same level as the follicular phase (first half) of the menstrual cycle, so it is still there performing its vital metabolic functions - we just don't need the high quantities we do leading up to and during pregnancy!

Hurdity x

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Suzyq

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Re: Evorel Sequi patches
« Reply #24 on: June 01, 2014, 10:54:58 PM »

Not all women do! Mine has consistently been at zero for at least 3 years! I can only share my experiences but lots and lots of women use progesterone to good effect - whether you subscribe to dr lee's view or not! Many women who have had hysterectomies and therefore have no need for progesterone, still supplement with this to achieve balance. I just think that women who still have problems after supplementing with estrogen, should consider whether they could be helped by steady progesterone levels - I have been! Honestly a massive improvement
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Rowan

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Re: Evorel Sequi patches
« Reply #25 on: June 02, 2014, 09:00:42 AM »

I have read every book Dr Lee wrote including his very informative text books, if people actually read them they might have a different point of view, and honestly its what works for each individual women that is important. He did not say women should not use estrogen by the way.

Its nonsense to  tell a woman that the regime that she is using ( if she chooses to share this knowledge) is not what she should be doing even if she is well and its working for her! Certainly HRT cause as many problems as it solves.

I have just read a sample on my kindle called "The Estrogen Errors: Why Progesterone is Better for Women's Health"  and will be buying it, very expensive but just reading the introduction and first chapter, it is compelling!

We are all different as is said many times, some ladies don't have there ovaries, some pack up due to loss of blood supply, other do continue to trickle out post menopause hormones until at least the age of seventy, also we also all different in our chemical makeup, so different hormones and regimes will work or not work for us.

I use a tiny amount of estrogen and quite honesty if I leave my patch off I notice no difference, I also use a small dab of natural progesterone too, and notice I sleep better and feel more calm, this works for me! It might not be right for the next woman, but what is important is to keep an open mind where hormones are concerned and take note when women post about what works for them.


 
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Milamam

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Re: Evorel Sequi patches
« Reply #26 on: June 02, 2014, 09:09:31 AM »

I agree, from everything I read thus far, there is no one single remedy for all women! I'll stick with femoston at least another month to see in the next cycle whether things will repeat re nausea on the progestogen part, and then discuss with Doc. I have taken Utrogestan before prior to getting pregnant with my second DD, and I don't remember causing any unpleasant effects. So if femoston is not working well, I will discuss patches and Utro separate. Hurdity, I agree, looks like trial and error.
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bev567901

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Re: Evorel Sequi patches
« Reply #27 on: June 30, 2014, 08:02:35 PM »

Has another month gone by? Next period has arrived one day earlier than normal this month. Took me by surprise I did not have much cramping, certainly no PMT or any of the usual headaches/sickness/etc etc. The second half of the month is definately better which still surprises me. I have had an extremely busy work schedule which saw me being awake 72 hrs straight at the end of last week plus an already extra busy work schedule on top of that plus all the usual home/kids stuff. Why was I not overwhelmed? I checked with my husband who agreed with me that I have been fine & he would not have guessed the timing. So all in all another big thanks to Evorel Sequi. The diazepam I am allowed is lingering in my medicine cupboard as are the zopiclone sleeping tablets I started taking regularly. Seems sleep is in short supply but by choice at the moment to do my job properly, not that awful insomnia that leaves you feeling so poorly.   It is so nice to feel steady & I can feel the old capable me returning with extra calmness. I can't explain it but it feels like I should be entitled to a bit of a mad wobble with all that is happening but I am able to break it down & just plod on with no stressing.  :sunny: :sunny:  B x
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Milamam

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Re: Evorel Sequi patches
« Reply #28 on: July 01, 2014, 05:36:37 AM »

Bev, it is wonderful that you finally feel much better! And yes please continue postint with good news, we all need this cheer ups!
Best
Mila
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Suzyq

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Re: Evorel Sequi patches
« Reply #29 on: July 06, 2014, 01:55:35 AM »

Good for you! It's nice to start feeling better .... Don't worry if you have a few wobbles, just keep on enjoying the good days!
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