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[VAR]

Can anyone tell me what oral dose of estrogen is equivalent to a 100mg transdermal estrogen patch please?

Many thanks!

[LittleClaire]

The equivalent is 300mg progesterone orally, that’s what I’ve been put on when I increased my patch from 75 to 100, I was on 200mg progesterone with the 75 patch.

[bombsh3ll]

I would say between 1.5mg and 2mg of oral estradiol hemihydrate as a rough guide.

However this depends greatly on individual absorption.

2mg oral estradiol may be a massive jump up for someone who has been wearing a 100mcg patch and absorbing next to nothing.

If I were postmenopausal I personally wouldn't take less than either 100mcg patch or 2mg oral estradiol for bone protection, with oral preferred unless I were to develop a clinical contraindication.

These thresholds have been cited by a panel of experts from the IMS as approximating physiological replacement.

That particular discussion was in relation to POI/early menopause, however whatever age my ovaries fail at, my bones heart and brain are just as important as a 30 year old's and I have yet to see any evidence that chronologically older menopausal women achieve the same outcomes at lower doses.

[VAR]

I would say between 1.5mg and 2mg of oral estradiol hemihydrate as a rough guide.

However this depends greatly on individual absorption.

2mg oral estradiol may be a massive jump up for someone who has been wearing a 100mcg patch and absorbing next to nothing.

If I were postmenopausal I personally wouldn't take less than either 100mcg patch or 2mg oral estradiol for bone protection, with oral preferred unless I were to develop a clinical contraindication.

These thresholds have been cited by a panel of experts from the IMS as approximating physiological replacement.

That particular discussion was in relation to POI/early menopause, however whatever age my ovaries fail at, my bones heart and brain are just as important as a 30 year old's and I have yet to see any evidence that chronologically older menopausal women achieve the same outcomes at lower doses.

Thanks - that's interesting! I'd heard younger women often need higher levels of estrogen because they are supposed to have higher levels. My menopause specialist mentioned it.

I suppose in my head I'd thought about HRT being in relation to symptoms, but you are right that maintaining a high enough level to maintain bone & brain health never stops being important.

Strong history of osteoporosis and early menopause in my family - but none of the older generations on Mum's side used HRT. I'm hoping to avoid going the same way.

[bombsh3ll]

"I'd heard younger women often need higher levels of estrogen because they are supposed to have higher levels. My menopause specialist mentioned it"

That's true.

However older women aren't supposed to have lower levels, they are supposed to be dead - we have only started outliving our ovaries in large numbers within the last century or so due to advances in living standards, hygiene and medicine.

So I know it's not the official treatment guidelines but I plan to replicate the physiology of optimal health rather than accept doses intended only to palliate vasomotor symptoms.

[LittleClaire]

So sorry, I read your post as progesterone not oestrogen oral dose. Peri brain! Ignore me