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Menopause Matters magazine ISSUE 82 out now. (Winter issue, November 2025)

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Author Topic: Reduced dose affecting me  (Read 207 times)

Puffin12

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Reduced dose affecting me
« on: December 08, 2025, 10:06:34 AM »

Hello everyone, advice needed please. I was on 75mcg patch with 2 utrogestan for 2 weeks of the month and very happy on this. Was on it for about 3 years. As I was reaching the age of 53 I tried the continuous regime of one utrogestan a day and bled heavily on and off for about 3 months. A scan showed a lining of 11mm and hysteroscopy was normal. I reduced patch to 50mcg on continuous regime and bleeding all stopped. This was 6 months ago. A recent scan (follow up) showed a lining of 8mm. I now have joint pain everywhere that is keeping me awake plus pain during sex despite starting on vaginal oestrogen. I am reluctant to increase to 75mcg due to thickened lining. I could double up the dose of progesterone but I worry about the risk of breast cancer as I have a cousin and grandmother why had breast cancer at young age. My concern is that I will need 75mcg dose for the rest of my life unless I am happy to put up with the joint pain. I just can’t decide what to do for the best. Any advice/similar experiences welcome.
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CLKD

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Re: Reduced dose affecting me
« Reply #1 on: December 08, 2025, 12:33:16 PM »

Quality of Life?  That bus might creep up behind U long B4 cancer symptoms appear!

As oestrogen levels falls the muscles may become lax = aches and pains.  Also the body may become dry: inside  and out = VA treatment is essential.  Every night if necessary we cannot overdose on oestrogen.

Some find that keeping a mood/food/symptom diary of use. I would increase the patch to get rid of the aches and pains.  No one should suffer!
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sheila99

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Re: Reduced dose affecting me
« Reply #2 on: December 08, 2025, 12:54:44 PM »

Yes, I get symptoms too when I try to reduce (anxiety, insomnia, hip pain, Va) so I have decided quality of life is more important than anything else, no breast cancer in the family though. Why not use the sequi regime that suited you so well? Or else more progesterone. I think the standard dose for conti is 2 utro daily now? They changed it recently. The synthetics are more effective or there's a mirena which I have now. I don't know much about it but think you can tested for the BC gene?
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CLKD

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Re: Reduced dose affecting me
« Reply #3 on: December 08, 2025, 02:40:05 PM »

Testing for the specific gene may well put your mind at rest , tnx sheila99.

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Puffin12

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Re: Reduced dose affecting me
« Reply #4 on: December 08, 2025, 02:59:39 PM »

Thanks everyone. I am seeing my GP next week so will have a good chat with her about it. I think I will go back on the 75 and double the progesterone. Thanks for replies
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bombsh3ll

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Re: Reduced dose affecting me
« Reply #5 on: December 08, 2025, 03:04:03 PM »

My approach would be to take the dose of estrogen that works for you and keeps you well, then titrate the progestogen to control your endometrium on that dose.

Dydrogesterone has just become available in the UK which is on a par with progesterone for being the least unfavorable in terms of breast risk, but is much more potent at lower doses for endometrial protection. Availability on the NHS is patchy but improving.

In terms of your family history, considering genetic testing would be a good idea, this would either qualify you for risk reducing surgery if positive or put your mind at rest if negative.

It is never worth suffering from untreated or suboptimally treated menopause due to fear of breast cancer because the additional risk is so small and in most cases outweighed by other changes the hormone therapy allows you to make such as being able to exercise and control your weight, which are far bigger risks.

Even if in the worst case scenario you had a BRCA gene, the difference that HRT makes to that already extremely high lifetime risk is absolutely marginal, akin to flying a jumbo jet and flapping your arms as well.

(I am a non carrier within a BRCA2 family, lucky enough to have had risk reducing mastectomies prior to the availability of genetic testing so I totally understand what it is like to live with that fear of will I be next).

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