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Author Topic: Progesterone intolerance. Struggling with Slynd.  (Read 129 times)

Lou23

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Progesterone intolerance. Struggling with Slynd.
« on: December 07, 2025, 05:27:25 PM »

Hi everyone. This is my first time posting. Very new to HRT but am really struggling with it. I’m 45. Perimenopausal and respond well to estrogel but micronised progesterone has been horrendous (orally and vaginally) so I’ve been prescribed slynd. 5 days in and I’m thinking of giving up because I’ve been so dizzy/brain foggy. I haven’t been able to run without feeling dizzy which is very unusual for me as I’m quite fit. So alarm bells are ringing. 

I’m petite, and do seem to have bigger reactions to drugs etc. wondering if anyone else has been in a similar situation and had any success with other hrt? I’m scared of mirena. Have a tilted uterus and already know from the micronised progesterone that it has a big effect.
Thank you x
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bombsh3ll

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Re: Progesterone intolerance. Struggling with Slynd.
« Reply #1 on: December 07, 2025, 08:10:42 PM »

Slynd (drospirenone) is a diuretic.

It dehydrates you and drops your blood pressure.

Some individuals get on really well with it but it is more suited to heavier women and/or those with higher blood pressure or prone to fluid retention.

There are plenty of other options.

Have you been on any kind of birth control in the past that you liked?
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Lou23

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Re: Progesterone intolerance. Struggling with Slynd.
« Reply #2 on: December 07, 2025, 09:22:51 PM »

Thanks so much 🙏 I was on dianette for quite a while which suited me quite well. I was maybe a little moody on it, but didn’t have any other side effects.
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