Hey Vicky, firstly to say I one million percent understand your desperation to find a regime that works for you, I have been there and at times felt like giving up, it’s been so so hard, I can’t even really put into words how hard it’s been and how unwell I’ve been but I really think you need to only be changing one thing at a time otherwise how are you going to know what is and isn’t working? Cerelle/desogestrel is less likely to fully suppress your cycle compared to Slynd unless you double up. I’ve been on this regime and know. Slynd is VERY good at suppressing your cycle, my fsh and lh on this are incredibly low, therefore if your aim is to suppress your cycle Slynd will do this, you need to give it a little time. Am I imagining it or did you say in a previous post you were on Yasmin? If so I think this uses drospirenone as the progestin so unlikely you are intolerant to it if you were ok on this combined pill. I still believe your issue is the Estrogen, not the progestin. Obviously I’m not medically trained and you must go with your doctor’s advice but do you keep a diary and notice trends? I’ve really found this helpful. For me, when Estrogen is too high or in comparison to progesterone I feel exhausted, low mood, irritable/angry, bloated, sore boobs… basically pms on crack. So many women report positive changes with higher Estrogen but this has been the opposite experience for me so I wanted to share my experience in case it helps. I really would try and change just one thing at a time, if you’ve lowered your Estrogen maybe stick with the Slynd and see if you feel any improvements. Just my opinion but honestly, constantly changing stuff really isn’t helpful in long run x