Please login or register.

Login with username, password and session length
Advanced search  

News:

Menopause Matters magazine ISSUE 82 out now. (Winter issue, November 2025)

media

Author Topic: Oral E vs Transdermal  (Read 1250 times)

Jessianner

  • Member
  • *
  • Posts: 15
Oral E vs Transdermal
« on: June 24, 2025, 01:35:38 PM »

I’m 33 & in surgical menopause for 3.5 years.
I have tried all sorts gels, patch’s, sprays. And although I feel ‘steady’, I’m still so lethargic, frumpy, brain foggy, forgetful, slow. I’m currently on Lenzetto and I am absorbing well.
I’ve recently read that oral E can help because of the metabolites being produced during first pass liver metabolism.
Has anyone switched from transdermal to oral and felt better?
Logged

sheila99

  • Member
  • *
  • Posts: 6026
Re: Oral E vs Transdermal
« Reply #1 on: June 24, 2025, 02:36:51 PM »

I've never used oral so can't answer the question. Do you know what your levels are? Just that what the the nhs considers an acceptable level is often way below what you feel good at. Will they let you try a higher dose or have you hit the nhs limit? In which case a private appointment might be your best option. You may be lucky with an NHS meno clinic but mine seems to be equally paranoid about prescribing more than 100mcg. What dose are you on?
Logged

Jessianner

  • Member
  • *
  • Posts: 15
Re: Oral E vs Transdermal
« Reply #2 on: June 24, 2025, 03:00:42 PM »

Sorry I should have probably included in my post that I don’t actually tolerate HrT very well. The more I use the worse my brain fog gets. I’ve tried transdermal in high doses & it made me more unwell x
Logged

bombsh3ll

  • Member
  • *
  • Posts: 2205
Re: Oral E vs Transdermal
« Reply #3 on: June 24, 2025, 06:08:16 PM »

I would say that the main advantages with oral estrogen are convenience and reliability, and for many, superior absorption.

Oral is also typically prescribed in more therapeutic doses as it was in widespread use before the WHI, whereas patches and gel largely entered the scene in an era when everyone was scared stiff of estrogen, so the doses considered standard, comparatively speaking, are lower.

I am not personally aware of any therapeutic benefits of hepatic metabolites regarding oral estradiol. In fact estrone, the main metabolite, is considered less favourable theoretically, and a reason why some prefer transdermal.

Personally I use oral because I don't want the mess, faff, cost, itching or lifestyle disruption of transdermal. I could bear the patches short term for IVF, however I am unwilling to sacrifice either exercise or hygiene to keep them on long term.

However everyone is different and at 33 you should certainly be able to get all options prescribed easily, so it is worth trying.

Additionally are you on testosterone? If not then the loss of this may be having a bigger impact than how you take your estrogen.
Logged