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[Goosieloosie]

I am a type 2 diabetic and recently got a CGM monitor and noticed my blood glucose seems much higher this week while I'm on the cyclical utrogestan 12 days course  foods that don't normally spike me are doing so this week. Last week before I began the utrogestan course I was actually pleased with how well my blood glucose was doing and how I appeared to be getting control with only diet and exercise. This is the first utrogestan course with a CGM . I have read synthetic progestin can raise blood glucose but not normally bio identical ones like the utrogestan. Can anyone enlighten me please have you had this happen? Appreciate any advice. I'm so disappointed this week and I eat very low carb .
I must also add I'm not new to utrogestan having been on this regime for almost 10yrs . I was diagnosed type 2 diabetic in March and this is my first CGM trial whilst on utrogestan.

[sheila99]

I don't know the answer but perhaps if you used it vaginally it would avoid the problem (assuming currently oral)? Possibly something in the casing?

[bombsh3ll]

Yes, progesterone (even our own) is known to raise glucose and reduce insulin sensitivity.

Think about the physiology of pregnancy. At the extreme end this is why some people get gestational diabetes when they weren't diabetic before, and it gets better after delivery.

If this is making your diabetic control more difficult, you may be better with a lower dose of progesterone continuously, than seesawing from zero to high progesterone and back again repeatedly.

[Goosieloosie]

I don't know the answer but perhaps if you used it vaginally it would avoid the problem (assuming currently oral)? Possibly something in the casing?

Thank you for your reply but I  did forget to put that I do use utrogestan vaginally.

[Goosieloosie]

Yes, progesterone (even our own) is known to raise glucose and reduce insulin sensitivity.

Think about the physiology of pregnancy. At the extreme end this is why some people get gestational diabetes when they weren't diabetic before, and it gets better after delivery.

If this is making your diabetic control more difficult, you may be better with a lower dose of progesterone continuously, than seesawing from zero to high progesterone and back again repeatedly.

Thank you, this does actually make perfect sense but I don't know what to do regarding using progesterone daily, utrogestan makes me so tired and I use it vaginally so I don't want to be doing that daily, as far as I know all other progestins are chemically made and I don't really want to use this type in view of my age which is 63. Do you have any alternative ideas? I am actually getting fed up with the bleed but surely using progestins daily would increase my blood glucose permanently?

[bombsh3ll]

Have you considered a mirena IUS?

This is synthetic but its effects are largely confined to the uterus.

Alternatively I would consider whether, like many women, you may be being over treated with progesterone in proportion to your dose of estrogen. Often women will be on a very low dose of estrogen yet prescribed standard doses of progesterone.

If you are under a specialist they may be happy for you to take either a reduced dose or a less frequent course of progesterone, so long as your endometrium remains in check.

This is not something you should just do alone however without endometrial monitoring.