Hi, I know it’s a couple of months on since your post, I just joined today.  I took Tibolone for the first time last week, as I couldn’t tolerate progesterone in any variety, and within 30 mins I had severe diarrhoea which lasted 4 hours.  After that, I just felt a bit weird, and the next day, I didn’t take any more but felt amazing!! Best I’ve felt in like 30 years!  However, have been too scared to take another tablet, as I felt I may have been having some sort of allergic reaction.  So doesn’t really answer your questions, but it did definitely have a bad effect on my stomach and digestive system.  Oh and I will mention I did only have half a tablet, at that.  Did you get any answers anywhere? Did you decide to give it another try? It can be so hard to know what to do, but we know we need to “something”!