Interesting question! I was just wondering the same lol.
I wouldn't risk estradiol on face etc, but I have always had a habit of steaming my face for cleansing effect/to clean out pores and for years I always found that ref clover gave me nearly magical effect. I have since started making my own soap (with all sorts of different things/herbs etc) because I can't tolerate any face washes. And recently moved to making face oils with combination of diff organic oils + red clover. So this is a far as I would go, herbs - Oil still infusing with Red Clover for testing.
But btw, apologies for going a bit OT, but most face washes are made with substances that clog pores, this is why now we have so many people with skin issues all over and teenagers the first time they start using proper skincare products. They first clog our pores with facewashes and then sell us products to unclog the pores and purify (kind of the same way as junk food manufacturers investing money in companies manufacturing products for fighting obesity lol).
So I use my soap, daily and let it sit on my face a bit longer during shower (no, it doesn't sting my eyes) and my skin has never been better for pores issues. The one I am on now is made with Aloe Juice, Goats milk and oats (all organic) with small amount of oils!.
I will be experimenting further to add things like sage to my soap kitchen
