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[mileee]

Hi I've had a blood test to check oestrogen levels and it shows I'm not absorbing.
I've tried up to 4 pumps of gel.
I've tried Evorel last year 50, 75
I've recently tried Estradot 50s
After checking the blood result it's like I feel worse. It's like for the past month the Estradot has been like a placebo.
I know I could possibly try oral, but I know there is a risk of blood clots. Even though I know it's a small risk and I'm not overweight, I still worry because my mum died of a blood clot aged 61 and her mum died of a blood clot aged 57. They were both obese though.
Maybe I'm just anxious because I'm not absorbing hrt.

[CrispyChick]

What was your blood level? What makes you think you are not absorbing? Did you have a baseline level?

I think it's weighing up quality of life over longevity. And how much your symptoms are bothering you. If you weigh if up, you might try oral.

Or there is tibolone too if you are post meno.

[bombsh3ll]

Oral estradiol is extremely safe. I am on it and my dad had.a portal vein thrombosis. I am active, eat healthily, don't smoke and am not worried about it at all.

The data showing increased risk of blood clots with oral estrogen was virtually all from synthetic estrogens combined with synthetic progestins.

Whilst there may be a marginally increased risk of clots with oral estradiol vs transdermal, this can be minimised by using either micronised progesterone or dydrogesterone.

Alternatively there is tibolone, which is a slightly different oral compound that has NO increased risk of clots.

You could also get a thrombophilia screen to put your mind at rest - this blood test checks for genetic tendencies to clot.

If this is negative, and you are a healthy weight, especially if you have had other "tests" in life such as pregnancies or being on birth control without developing blood clots then I wouldn't worry.

[SundayGirl]

Are you a medical professional bombsh3ll?

Just wondering as your posts appear to show you have extensive medical knowledge about an awful lot of things.

[mileee]

I checked my blood result on NHS app and it said oestradiol was less than 88 which indicates probably not absorbing.
I've had previous blood tests when I've tried different methods of transdermal HRT and they've all said E2  less than 88.
Thanks for the reassurance about oral HRT.
It really helps.
I've got an appointment with GP to discuss what to do next in 12 days time ( counting the days).
My sleep has got worse since seeing the results. Been awake since 4am with anxiety and have to go to work.
It's so hard, but thanks for this. It gives me hope

[Dramy3]

Hey
I’ll echo the reassurance from bombsh3ll. Here’s a link to the summary of data and guidelines that GPs use in decision-making:

https://gpnotebook.com/en-GB/pages/gynaecology/thrombosis-and-hrt

You’ll see the risk is 18 in 10000 women. And that’s based on very old data mostly using synthetic hormone preparations that aren’t regularly prescribed anymore. And these data included much older women whose cardiovascular risk naturally increased with age. Plus this is WHI data which is so flawed (another discussion!)

NICE guidance also dictates that women with a higher risk of VTE should be referred to a haematologist for additional testing if an oral HRT is to be considered. So basically, if the GP says no, you should be referred.

Good luck!

[mileee]

Thanks for that information.
It's so time consuming to just Google and search for answers when it's going round in my head.
I really appreciate it.