Since August this year I have used Vagifem, Vagirux and Estriol cream, at times together and separately. My GP did not want to prescribe both or want me to use both together, as many women do. My symptoms were UTIs, soreness and burning. I had a few urine tests and a swab test, which both came back ‘normal’. After 3 months I went to see a private gynaecologist as I was still sore. She said to use Estriol internally and externally every other day as it was a ‘better’ form of hormone. I don’t know what she meant but I am certainly much better using the cream. Maybe it works better on sore skin and it easy to apply everywhere, including around the urethra. It is a bit messy though and I miss the convenience of Vagifem. (I was concerned about the amount of plastic waste with Vagifem and have also used Vagirux, which has a single applicator to wash and reuse. To me they work and feel just the same.) I am also using Cetraben ointment as a barrier cream. My GP is happy for me to use Estriol every other day since the gynaecologist says it is ok. I hope you feel better soon.