I went through pof at age 36 and was put on 100mg patches sequi, all was fine for 13 years then I started having heavy bleeds and clots, scan showed a very small fibroid and the consultant said because of my age 49 at that time that 100mg was too high and it was reduced to 50mg all was fine for 3 months then I started bleeding heavy again she then changed me to continuous at the age of 51, 25mg evorel patch and 100mg utrogeston continuous, the first 3 months my periods were irregular but so much lighter now they have stopped (I hope)