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Author Topic: Estrogen levels and Slynd  (Read 9922 times)

PennyD

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Estrogen levels and Slynd
« on: July 01, 2024, 08:48:12 PM »

Hi all,

I've been on Slynd 4mg as the progesterone element for HRT for 3 months, along with a 50mcg patch. All great, I'm so happy with this progesterone.
However, after my last consultation, my doctor increased my oestrogen to 50mcg and half of a 25mcg patch, with a view to getting me gradually to 75 mcg. I increased the patch for the first time 4 days ago and put a new lot on this morning. This evening I'm cramping and spotting. It's very slight, but unusual as I've not had any periods at all for over a year (I'm 46). Really I don't want to be taken off anything, the increased oestrogen is making me feel fantastic and this progesterone is a game changer for me.
I'm not sure if this is the increase in oestrogen, or a sign that my progesterone isn't enough. I've also switched from taking Slynd at night to in the morning.
Has anyone had similar experiences when increasing their HRT regime, especially on Slynd?
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bombsh3ll

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Re: Estrogen levels and Slynd
« Reply #1 on: July 02, 2024, 04:29:48 PM »

I have no personal experience with Slynd but 4mg of drospirenone is more than adequate for endometrial protection - for comparison Angeliq which is oral combined contains 2mg.

And you are only 46 so may still have some endogenous ovarian activity.

I wouldn't be concerned about this at all, it is common to get a bit of bleeding in the first few months after a change in HRT.

If it persists beyond 6 months or so, that's when I would think about a scan for reassurance.
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Hurdity

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Re: Estrogen levels and Slynd
« Reply #2 on: July 02, 2024, 09:00:31 PM »

Hi all,

I've been on Slynd 4mg as the progesterone element for HRT for 3 months, along with a 50mcg patch. All great, I'm so happy with this progesterone.
However, after my last consultation, my doctor increased my oestrogen to 50mcg and half of a 25mcg patch, with a view to getting me gradually to 75 mcg. I increased the patch for the first time 4 days ago and put a new lot on this morning. This evening I'm cramping and spotting. It's very slight, but unusual as I've not had any periods at all for over a year (I'm 46). Really I don't want to be taken off anything, the increased oestrogen is making me feel fantastic and this progesterone is a game changer for me.
I'm not sure if this is the increase in oestrogen, or a sign that my progesterone isn't enough. I've also switched from taking Slynd at night to in the morning.
Has anyone had similar experiences when increasing their HRT regime, especially on Slynd?

Slynd is listed on the British Menopause Society's list of suggested alternatives to licensed HRT products in cases of progesterone intolerance. It is given as suitable for opposing medium oestrogen doses but doesn't give any progestogen equivalents for higher oestrogen doses than 2 mg oral or 50 mcg patch.

Interestingly the amount in Slynd at 4 mg, as bombshell says, is higher than that given for angeliq at 2 mg (no longer available here). In other instances, the mini pill (POP) contains LESS progestogen than the HRT combined pill equivalent, hence the need to take two mini pills when used off-licence for HRT eg with Cerazette - desogestrel.

It could be the increase in oestrogen causing the bleeding or your own cycle breaking through. When you say you did not have periods for a year - wwere you taking any HRT before your current regime, or any contraceptive? Unless you have been without a NATURAL period for at least 12 months (and this is a conservative estimate) you cannot know when you reach menopause once you've started HRT.

Do you take the placebo pills or do you take it continuously?

It is very unlikely that increasing oestrogen by 12.5 mcg would result in cramping and bleeding 4 days later. If you changed the time you took Slynd to the morning at the same time ie a few days ago, then theoretically the slight drop in progesterone levels may trigger spotting, if the womb lining had thickened slightly - because there was a longer interval between doses.

However I do agree with bombshell that you don't need to be alarmed as yet, unless the bleeding becomes heavy or if you sense that something is wrong, and wait for 6 months, then ask to be referred. There are new detailed guidelines detailing how and when to be referred...

All the best and hope you continue to feel well.

Hurdity x
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Sugarant

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Re: Estrogen levels and Slynd
« Reply #3 on: July 03, 2024, 10:33:07 AM »

I've read this thread with interest, as I've just been prescribed Slynd 4mg to go with 150 Estradot patches. I hadn't had a period in about 2.5 years when my clinician upped my estrogen dose from 100 to 150 last September, at which point I started bleeding and basically haven't stopped. Even when I went back to 100 patches for 4 months, the bleeding continued, so she's now switched me from 2 x utrogestan to continuous Slynd tablets, skipping the sugar pills.

I think increasing the estrogen would see a bit of breakthrough bleeding and as others have said, I wouldn't be worried yet. I thought my consultant would be worried that I'd been bleeding for over 6 months, but she wasn't and now we're waiting to see what effect the Slynd has. It is such a pain to suddenly start bleeding after a long time of no periods though, so I do sympathise!
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joziel

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Re: Estrogen levels and Slynd
« Reply #4 on: July 03, 2024, 12:01:27 PM »

It's very normal to bleed after increasing estrogen dose and the advice conventionally given is to disregard any bleeding that occurs within 3 months of an increase. Just continue as you are and it will resolve.
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karab

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Re: Estrogen levels and Slynd
« Reply #5 on: July 04, 2024, 06:53:27 AM »

Also, thought I might add that my experience has been that significantly changing the timing of my slynd dose actually /usually/ causes spotting.  Sometimes even if I only change it by a few hours.  The spotting also sometimes doesn't resolve by the next day, sometimes it continues for a few days.

This is purely anecdotal, but I read other reviews about it before I started that complained of the same thing, and said for minimal spotting, try to take it at the same time every day.  Also, if you started recently, lots of people complain about unscheduled bleeding in the first 3 months.

Kara
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PennyD

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Re: Estrogen levels and Slynd
« Reply #6 on: July 09, 2024, 01:19:06 PM »

Thank you all, that's very reassuring. I'm taking Slynd continuously without the placebo pills. Hurdity, yes I've been on birth control continuously for years and then trying out various forms of HRT so yes I can see that this might be a period. A week later, brown spotting has turned red and slightly heavier but nothing unmanageable. I've got all the same period symptoms that I remember - hunger, sugar cravings, cramp, low energy, really hoped I wouldn't see this again! However I've stuck to the increased Estrogen dose, it's worth it and hoping this resolves soon. Also, I'm sticking to taking it at 10pm every night, after your advice, otherwise it seems to cause sleepiness during the day. Many thanks, don't know what I'd do without this forum.
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Hurdity

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Re: Estrogen levels and Slynd
« Reply #7 on: July 09, 2024, 07:50:54 PM »

Hope it works for you - do let us know.

Hurdity x
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LuLuRose

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Re: Estrogen levels and Slynd
« Reply #8 on: September 07, 2024, 04:31:50 PM »

Hi All
Sorry to jump on this thread hope that is ok.
I am 10 years post menopause, been stable on Tibolone for many years until a few months ago when started bleeding out of the blue.
Womb lining was 13mm when scanned but biopsy clear.
Was prescribed Slynd 4mg, in addition to Tibolone (taking Slynd same time each night and Tibolone in the morning).  Taking continuously so ignoring the non-active pills.
This stopped the bleeding for 4 weeks.
Then out of the blue after a month of no bleeding and feeling great, the bleeding started again.  It's been heavy for last 2 weeks.
I opted for Slynds as it has same progesterone as the Yasmin birth control pill which really suited me back in the day.
Feel well on both HRT's and reluctant to come off anything.
Anyone any ideas why this would be happening?
Thanks a million
Louise x
« Last Edit: September 07, 2024, 04:36:25 PM by LuLuRose »
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joziel

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Re: Estrogen levels and Slynd
« Reply #9 on: September 07, 2024, 04:38:09 PM »

You might want to consider a Mirena coil, which will solve your bleeding issues for 5 years after it's in...
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LuLuRose

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Re: Estrogen levels and Slynd
« Reply #10 on: September 07, 2024, 04:41:31 PM »

Thank you so much Joziel I did suspect I may need to try that.  Every HRT I have tried historically put weight on, hence the reason for my nervousness with the Mirena coil. Really appreciate your reply
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joziel

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Re: Estrogen levels and Slynd
« Reply #11 on: September 07, 2024, 05:08:17 PM »

The Mirena only has a tiny amount of progestin in it and the majority of that stays local to the uterus. The levels in the blood are tiny compared to taking an oral progestin.
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LuLuRose

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Re: Estrogen levels and Slynd
« Reply #12 on: September 07, 2024, 05:31:39 PM »

Thanks so much looks like I may need to try that.  Any idea why I'm bleeding on the oral progesterone, is it because the oestrogen (from tiblone) and progesterone levels are not balancing?
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AngelaH

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Re: Estrogen levels and Slynd
« Reply #13 on: September 07, 2024, 05:52:19 PM »

Any idea why I'm bleeding on the oral progesterone, is it because the oestrogen (from tiblone) and progesterone levels are not balancing?
Tibolone is known by its tissue-selective activities, it means it doesn’t have effect on uterus and breasts. But some ladies do report that Tibolone causes bleedings for them. I don’t have any explanation why it happens. I am personally new to this type of HRT, just have started taking it a month ago, so have no personal experience or knowledge of my own.
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LuLuRose

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Re: Estrogen levels and Slynd
« Reply #14 on: September 07, 2024, 05:57:18 PM »

Many thanks Angela that's interesting.  I have been settled on Tibolone for about 6 years, have absolutely loved it.  It gave me my life back.  So weird that the womb lining has thickened and I'm bleeding after no issues for so long. Adding the Slynd to the Tibolone initially did the trick but now back to square one
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