It depends on how sore, itchy, dry the vagina might B. I push the ovestin applicator as far in as possible. Sometimes it's more comfortable to start with a gentle push which should, as the preparation work it's magic and softens the skin, allow a deeper insertion. If U find that half way suits your symptoms, then stick with it. It's the amount of nights per week that is important for many, some require treatment every night others vary depending on how the vagina feels.
When my belly begins to feel full: around the surgical bikini line: I know that symptoms are trying to be problematic so up the dose immediately; sometimes in the middle of the afternoon then at night.