Yes, this is exactly the same for me Maggie.... I had zero internal vibrating and zero sleep problems (hypnic jerks, heart beating hard and fast etc) until I STARTED HRT. It actually got worse/more intense with each dose increase.
Starting HRT fixed all my 'typical' low estrogen symptoms almost immediately - but 3 weeks after beginning HRT, I got hit with these awful internal vibrations/tremors and all the night time symptoms.
Like you, at first I thought it was the HRT itself. I spent ages slicing up patches to increase incrementally (I was only on a low dose then, 50mcg at the most). When that didn't help, I stopped HRT altogether for 6 months. This didn't fix the night time symptoms/inner tremors and I also got back all the usual low estrogen symptoms.
I introduced progesterone/utrogestan by itself for a few months. No change in these symptoms.
Then I re-started estrogen, and this time things didn't get worse with each increase - in fact there seemed to be no change in how I felt with these inner tremors. (Other than the low estrogen symptoms went again.)
It was then I realised that my estrogen levels in bloods were never very high. They were actually pretty low. On one occasion they were 400pmol-ish but that was because my ovaries produced some then. When I consistently tested during my period to rule out what I was contributing, it was low.
So as I'd tried no HRT and I'd tried the regular doses of HRT and as my levels were never that high, I decided to go in the other direction and get my estrogen to between 400-600pmol as recommended by the Newson Clinic doctors. At this point I discovered that I absorb transdermally very poorly and need a high dose to get enough.
And yes, 400-600pmol is my estrogen level I am aiming for. If you are in the US, that is around 115 in your numbers. There is a great group on Facebook which is US based called 'Bio-identical Hormone Replacement Therapy' if you are on Facebook...
I would add that I don't think this is about 'low' estrogen and certain women doing better on 'higher' estrogen - because I have a history of endo and after my laparoscopy in 2014, I was put on the desogestrel POP to keep my estrogen low. This worked and I had no endo flares for the 10 years I was on it. So - my body is *used* to having relatively low estrogen and certainly not estrogen in the 400-600pmol range for the last 10 years. So these inner tremors etc, in my eyes are not about LOW estrogen - they are potentially about fluctuating estrogen, ovaries spurting out some and then none with no pattern or cycle or regularity to it. Taking a higher dose of estrogen overrides these fluctuations and smooths things out.
