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Author Topic: Nausea on Continuous  (Read 1144 times)

Mogster71

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Nausea on Continuous
« on: January 28, 2023, 09:11:14 PM »


I'm 51 and still (I think) peri-menopausal. I started HRT in 2019, first tablets and then patches, both on a sequential regime. Each time I have historically settled on something that good feeling has lasted for 6-9 months before I've needed to increase. My main symptoms are crippling headaches which come daily, a bit of VA, if there is such a thing.

I sought specialist advice in September last year after a return of headaches. I had been taking oestrogel 3/4 pumps and utrogestan on a 2 weeks on, 2 weeks off basis. I was having 2 periods a month sometimes, and the suggestion was that I should move to continuous progesterone to try and even out the fluctuations in hormones that I seem sensitive to headache wise. I opted at that time to go back to patches as I was finding 4 pumps of gel a faff. First we tried Femseven 75 but they wouldn't stick no matter what, and so we went to Evorel and as I had been on 4 pumps of gel we went to 100.

The only thing that the switch to continuous has solved so far is that the headaches have gone, which is brilliant. However, when I first started this regime I had nausea and assumed it would ease after a couple of weeks, but it really hasn't. I've tried taking the Utro vaginally but it causes a lot of irritation which is awful. My boobs were so sore I could barely tolerate a shower on them, but that has settled. They feel heavy though but I am small busted so I don't mind the boost! I'm also having at least 2 bleeds a month, and they are full on bleeds, not just spotting.

I am wondering whether my body is just not ready for continuous yet, as I had minimal nausea on the sequential. Either that, or I wasn't absorbing the gel properly so the jump to 100 Evorel is too much? I am guessing my only options are to return to sequi or drop down a bit on the oestrogen patch, or possibly even a long cycle sequential - if that works on a high-ish level of Evorel. Does anyone have any thoughts or has been through this themselves please?

thank you in advance




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Dotty

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Re: Nausea on Continuous
« Reply #1 on: January 29, 2023, 07:35:44 AM »

Hi if you’re still peri then a continuous regime won’t stop the bleeding….it could make it worse .

Nausea for me was a symptom of low oestrogen but it could be too mush oestrogen too. x
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Mogster71

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Re: Nausea on Continuous
« Reply #2 on: January 29, 2023, 09:07:21 AM »

Hello Dotty

Thank you for your kind reply, I really appreciate it. Its such a fine balance between too little and too much isn't it? I need to not have headaches every day but not so much that I am permanently queasy. Ugh. I thought it would settle down as it usually does but I wonder if the oestrogen is just a bit too much as I'm having it by patch rather than gel now and absorbing it better, maybe I should have settled at 75 first on patch to see how I got on.

My mood has definitely not improved, I feel like I'm a lot more irritable. Moving the progesterone to mornings has been better for my energy I think, because I couldn't get going in the mornings when I took it at night.  I was getting 2 periods a month sometimes on sequential as well, I think that was her theory that eventually the bleeding would settle down but I'm 4 months in and they seem to be as heavy as before if not worse, plus the unpredictability of the bleeds. x





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Mogster71

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Re: Nausea on Continuous
« Reply #3 on: January 30, 2023, 03:33:30 PM »

Dotty can I ask why bleeding would be made worse on a conti regime if I am still peri please? Just trying to get as forwarned/armed as possible to go to my GP and ask for what's needed now.
Thank you very much x
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RebJT

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Re: Nausea on Continuous
« Reply #4 on: January 31, 2023, 01:27:53 PM »

Hi

Not sure I have any solutions as I'm in the same boat.  The meno specialist I spoke to said I have a strong cycle underneath (I get heavy bleeds too, although until I increased E on sequi, they were always regular) and I'm properly into peri, but not far enough in to be able to handle conti.  She likened it to trying to put a 'lid on a boiling pot'.

So like you I'm at the point where I need 4 pumps of gel, but I can't hande the dose of progesterone I'd need to balance that out.  I've recently had a one cycle disaster trying conti utrogestan, and it made me feel so utterly awful, jittery, revved up, sleepless - yet when I take it sequi, it does the opposite.  According to what I've read (from Louise Newsom and in the BMS meno management guidelines) the whacky bleeding is because the endometrium is not yet stable enough, plus we'll be having a random zap of hormones from our sputtering ovaries, as the HRT won't override our own cycle.

It's frustrating.  Boob soreness - I read somewhere that WHERE the soreness is can indicate the issue and if it's at the front and around the nipple that usually indicates it's oestrogen, and around the side and under the armpit is more prog.  I'll try to remember where I read that.  Another thing I've found super helpful is tracking my symptoms on a calendar.  Day 1 - 28 across the top, and then a list of symptoms down the side (breast pain, water retention, weight gain, hair loss, sweats, jittery, sleep issues etc) and I score them 0 - 5 (5 being the worst they can be), this would over a cycle or two, quickly show you if your symptoms follow a pattern in line with your underlying menstrual cycle.

Re absorption I've been advised to test my E on the same day of my cycle (day 5) for a few months to just check the absorption issue, for £50 at the Nuffied, I thought it was worth a go! We will see.

Some women with bleeding issues seem to do better on 200mg utro a day, although not all of us can cope with that much, and from what I gather it can take several months for it to settle down.  I think in that instance the wisdom is orally is better than vaginally for bleeding.  I'm in a facebook group run by Jane Pangbourne (who runs Menopausal Not Mad) - it's quite strictly moderated, but this means they keep it really factual, I've gleaned quite a lot in there (I think half my issue is HRT education, nobody really takes the time to properly teach us about HOW to take this stuff properly, and in hindsight some of the changes I've made would have been better handled with tweaks to doses, rather than wholesale changes of regime).

Anyway, in sympathy!

Reb
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