Hi vicky, sorry to hear how much you are suffering with anxiety I too have been there, still am at times, I can only speak from my own experience, but 4 pumps of estrogel is alot I started on two at 43 and stayed on that dose for a long time, when doctors moved me up to higher doses it sent my anxiety sky high, I stuck with it for ages but I couldn't physically leave the house it was awful, I dropped the dose back down and within a couple of weeks the anxiety became much less, but obviously that's only my experience, but high doses are not always the best way to go, my gp still insists I should be on a higher dose due to my age but my body just doesn't tolerate it, maybe its worth trying a lower dose, I wish you well as I know only too well how horrible anxiety is, I've also come to terms with managing my anxiety in other ways, as hrt was not a complete cure for me, Im now able to function, it's still there at times but it no longer controls me x