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[laszla]

I also found Utro used pv irritant to whole GU tract, but both Utro & MPA also irritate my bladder when taken orally, though not to same extent.  Like Kathleen & Cassie, Utro also makes me horribly wired, extremely hot & sleepless with bad palpitations, however much oestrogen I've taken with it & whatever the route.  Though never tried the back door 

Back door definitely worth a try. Like so many things, administration route preferences/customs are often culturally determined, eg. on "the continent" suppositories are widely used in comparison with UK. I'm half French/Italian and in those countries practically every ailment from a headache to car sickness and worse has people reaching for a suppository as the active ingredients are considered better absorbed. 

[Wrensong]

Great tip laszla.  Thank you.

[Jaylow]

Never tried it orally so can’t compare, but vaginally makes me need the loo more, dries me out and irritates me externally as the powder stuff comes out the following day.

[pepperminty]

I also found Utro used pv irritant to whole GU tract, but both Utro & MPA also irritate my bladder when taken orally, though not to same extent.  Like Kathleen & Cassie, Utro also makes me horribly wired, extremely hot & sleepless with bad palpitations, however much oestrogen I've taken with it & whatever the route.  Though never tried the back door 

The progesterone in Prempac C when I took it, did exactly the same to me, hot and sleepless nights and heart racing. But the estrogen in it worked a treat and all my aches went ( felt a bit queasy but ok) . 

Shame they do not do more research into the rectal route and side effects as this may be the way to go for some ( if you see what i mean ).

PMX

[Wrensong]

Funny thing is using it vaginally constipates me badly but I'm ok using it rectally.

Avalon, that's odd isn't it, but then what isn't bizarre about menopause?  Nothing surprises me anymore .

The progesterone in Prempac C when I took it, did exactly the same to me, hot and sleepless nights and heart racing.

  Oh, it's just the pits Pepperminty when one bit of a regime works well & the other undoes all the good & more.
Wx