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[Annies]

Hi all,

Had blood results back last wk showing oestradiol level of 795 which, after some googling, I believe is really high??
I'm on a continuous regime of utro 100mg orally plus only 1 pump estrogel so surprised it's this high. The hormone specialist I saw a few months ago had advised to increase to 2 pumps if anything but I've stuck on one to date!
Am due a follow up end March so just interested to hear from others in meantime as I feel I'm having def symptoms of estrogen dominance- v sore nipples/ breasts and v wakeful sleep. Wondering if I should be decreasing to half pump if anything. ..?
(Still having periods but v variable cycle length...)
Thanks!

[Salad]

Just wondering - Was the blood test done soon after you had applied the gel?

[Annies]

Hi Salad,

No it was done at 3pm and I'd applied the gel at around 10am...🤔. I've no other recent tests to compare with ( only more HRT and it was about 100 or so). but from what I've read about "normal" levels it's pretty high? Maybe I'm worrying unnecessarily but loathe to increase the dose on that reading esp as my sleep & skin are so dodgy!

[Uptick]

Hi Annies, this is a normal reading for pre and perimenopause. One pump of Oestrogel is nothing compared to perimenopausal oestrogen levels. Is this regime controlling your symptoms? I guess it's the progesterone that's balancing oestrogen fluctuations, not the extra oestrogen in one pump.

[Annies]

Thanks Uptick.
So you think the lion's share of that reading is attributable to my own oestrogen production? I justvassumed I'd not be producing anywhere near that amount as pre HRT levels were always around 100 or so. Bit I am still perimenopausal and have erratic cycles so I guess will be ovulating still occasionally.
Heat at night is controlled by the HRT, but it hasn't worked wonders for my insomnia unfortunately, which was a key reason for giving it a go.

[Uptick]

Yes, I think so. Blood tests are just snapshots and daily fluctuations can happen in perimenopause. I thought 100mg of continuous Utrogestan would help with insomnia, but maybe it's the wild oestrogen fluctuations that are keeping you awake. I also had terrible insomnia in perimenopause.

[Annies]

Appreciate your thoughts on this Uptick, thanks.
If only there were a magic wand...!

[Erika28]

Where do you apply your Estrogel?

[Floo36]

I don’t think 1 pump of gel is capable of delivering that much Estrogen it will be your own Estrogen and could have been a spike in Estrogen when the blood was drawn.  It is near on impossible to get accurate blood levels when there is so many fluctuations going on.  I know I’m in the middle of it all trying to get enough Estrogen in me to get me well.