Yes, I have had bladder irritation with Utrogestan, and repeated UTI's. I think there are a few women who have reported similar on the Menopause Matters Forum. It was suggested that I try vagifem with Utrogestan but I still experience discomfort. I know there is a study somewhere on the internet that shows the percentages of women who experienced irritation with Utrogestan. I think Utrogestan is a diuretic so passing urine more often goes with the territory. I have read other posts that suggest increasing the estrogen?