Oh that's so spooky CrispyChick! I just saw your first post of today and thought whilst I was reading if I should mention the DIM I am taking and then I saw you mention it further down in your post!!!
I tried DIM in 2017 (I know that as I am now taking the one I bought then and found the date on my Amazon account). I had a very strong reaction to it back then, as I did with most things, with palpitations etc and stopped immediately. I clearly held onto the pack to potentially try when hormones were more settled.
Anyway, I saw it mentioned on a Facebook group (probably the oestrogen dominance one) where a woman was taking it alongside transdermal HRT and said that she cannot take Estradiol without taking DIM as she is very sensitive to oestrogen. Apparently the DIM does not reduce oestrogen, it just allows the liver to metabolise it properly. This also means it stops testosterone from converting to oestrogen so it also boosts testosterone. It is also recommended for men to reduce enlarged prostate, which is caused by their testosterone converting to oestrogen.
I started it last Sunday (10 days ago) and I had an excruciating headache that came and went for the first few days. I then did more research and saw that this was short term and not to stop as it was a good sign, even though many give up thinking its doing something harmful. Since then I have felt very good and much more balanced with almost zero of the low-ebb constant anxious feeling - I am not taking anything else but it can, as above, help to take alongside HRT.
The testosterone bit was interesting as I have felt nervous driving for the past few years and even when on the progesterone cream, when the most relaxed, this only reduced a little. (I do have to drive late at night now on M25 as my parents moved an hour away and I try to visit weekly after work). Last week I was whizzing along the fast lane as I did when younger and didn't feel nervous at all and I wonder if this is the testosterone! I have tried the cream but it used to make me feel as if I had PMT - potentially it was converting to more oestrogen?
There is a lot to read up on DIM but it is basically from cruciferous vegetables and converts the more harmful estrogen into the healthier form.
I was going to wait before posting about it anywhere as very early days but had to reply!
This link is from an excerpt of a book and gives more info.
https://fortwaynephysicalmedicine.com/blog/the-benefits-of-dimIn terms of the high dose progesterone cream, I found 100mg twice a day was enough to crowd out the excess oestrogen but a few years ago I didn't get the same relief so potentially did need a very high dose. Jan Toledano from LHC did used to work with MG and she always said try to get as much as possible in you. I don't think I ever took it high enough as my oestrogen spikes were silly high.
Just to add that I read many accounts of DIM reducing breast lumps and it can be protective against many cancers as stated in this research report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964527/