Hi Nik2502,
I feel exactly the same- depressed, detached, shabby and decidedly odd (it's difficult to articulate!)
I'm literally on half a pump oestrogel per day and this is day 4- so, stupidly sensitive!
My bloods cannot detect any oestradiol and I'm shattered so really need this oestrogen.
Hopefully for both of us this is, as you say, our bodies adjusting.
Sorry, not much help- but hopefully you can take some comfort in the fact that the oestrogel is affecting me similarly!! And fingers crossed this is all temporary for both of us