Haha, next time I'll choose blue, sometimes this subject gives me the blues, so quite appropriate. I thought red was ok to highlight a potential danger, but I agree that it doesn't suit presbyopia
Thank you for the explanation, the math is quite simplistic and doesn't mean anything in terms of how much is being absorbed by local cells. The statement is misleading, it reassures women that topical is safer than oral but doesn't address the issue in question which is: is topical oestrogen safe in the long term? It's also disconcerting that oral estrogen is used as comparison when oral tablets are still being prescribed and sold in large amounts.
Conolly X
Haha that's why I use green - as it is calming! (CLKD go to the first page and you'll see the red unless you are colour blind?)!
Yes it is totally simplistic! I assume it was a simplistic way of getting the message across that the amount in Vagifem is tiny compared to systemic HRT - because people understand it - it's a ballpark thing rather than precise measurement!
I'm not quite sure what you are worried about? As has been said earlier in this thread - long term effects of vaginal oestrogen have not been measured and this is recognised in the HRT guidance from BMS - I'm sure I have referred to it down thread? However the stimulating effect of oestrogen on the endometrium is dose dependent and this is well documented therefore the minimal risk is by extrapolation in the absence of hard data and long term trials. As with all treatments it is a question of risk (of endometrial cancer) - which is estimated to be extremely low - even if theoretically possible.
I'm also not sure why you are disconcerted re the oral oestrogen? Provided any oestrogen is combined with the appropriate dose of progestogen for women who still have a uterus - then the risk of endometrial cancer is minimised.
There is no need for women to be alarmed at all - we have recommendations drawn up by the experts in the filed who have examined the evidence and drawn their conclusions - but as always with any hormonal treatment - be sensible and vigilant, and only deviate from the licensed regime in consultation with your medical professional.
Btw Conolly are you American/living in US?
Hurdity x