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Author Topic: Oestrogel and Oestrodose - they are exactly the same  (Read 45480 times)

Jeepers

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #135 on: November 28, 2019, 06:44:32 PM »

Hi Hurdity

Thanks for your reply :-)

I should have said that the oestrodose smells much more strongly of alcohol, so much so, that my partner remarked on it.  I know you explained a lot,fab,  and it makes sense, but I definitely felt different on it, so its all a bit strange.   I will look up the yellow card scheme, thanks for the heads up.

Oh, and I'm 4 years post meno, but only on HRT for 18 months

Jeepers xx
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bear

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #136 on: November 28, 2019, 07:01:11 PM »

Hi Jeepers,

My sister has been on Oestrogel for ages and the only time she was given Oestrodose she felt there was a difference. I wonder if this could be due to the fact that at least until 2016 there were 2 different sites of manufacturing, one in France (Montrouge) and other in Belgium (Drogenbos). Now they all seem to be manufactured in Belgium. Do you have the lot/batch number of this Oestrodose bottle?

BeaR.


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Jeepers

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #137 on: November 28, 2019, 07:24:54 PM »

Hi

The bottle says Lot: 72420
Exp: 07/2021
PL: 20774/1551
ECMA: 3400933829247

Jeepers xx
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bear

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #138 on: November 28, 2019, 07:40:44 PM »

Thank you, Jeepers.

According to the expiry date it has been manufactured in 07/2018, probably in Belgium, but maybe some batches are still from France. Are you going to keep using it?

BeaR.
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Hurdity

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #139 on: November 28, 2019, 08:16:38 PM »

Here we go again....

This issue has been rumbling on for several years irrespective of where whatever batches have been manufactured at which of the besins plants. You're (bear) trying to look for unlikely explanations for potentially minute differences bear. As far as we know they are all manufactured in either France or Belgium by Besins to exactly the same recipe ( well they haven't  counted the molecules  ;D ). The previous discussion centred around manfacturing sub-standard products in Asia, Oestrodose being a cheaper generic, even weird discontinued ingredients like benzene from old formulations that were stopped in the 90's etc etc. Besins' answers debunked that. Let's not go over all the same ground again.

What is important is Jeepers reaction. Jeepers - like I said - I would send that info to Besins along with the consistent differences in symptoms and sdie effects you experience on that batch (and for consistency i would try a couple of weeks or something back on it again so that you are sure it's not coincidence) and also the details of the yellow card scheme are here:
https://yellowcard.mhra.gov.uk/

It is important to report to them and to Besins so that they know if there is a difference and can perhaps explain to you? You could also write to them with that information. Their e-mail address will be on your patient leaflet - or if not, on the emc website here:
https://www.medicines.org.uk/emc/product/353/smpc#companyDetails

Also the licence number  (the PL bit - 20774/1551) shows it was given to Quadrant pharmaceuticals in Jan 2018 for the import of oestrogel pump pack! So I would defo write to Besins with the batch number etc... Let us know what they say - whatever it is :)

Hurdity x



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Tinkerbell

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #140 on: November 28, 2019, 08:18:21 PM »

BeaR, i have used Estrogel for 3 years and in that time i have ended up with Osterodose three times and that has concided with a flare up of my symptoms.
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bear

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #141 on: November 28, 2019, 09:54:44 PM »

BeaR, i have used Estrogel for 3 years and in that time i have ended up with Osterodose three times and that has concided with a flare up of my symptoms.

Hi Tinkerbell,

That's exactly what happened to my sister. They are supposed to be identical, but if there was any change in manufacturing sites, even if the 'recipe' is the same, the raw materials and fillers may have come from different sources and small differences (legal) are bound to occur. I suppose Besins has already established that the manufacturing facility at Drogenbos in Belgium is the sole source of Oestrogel/Oestrodose now and as the UK has its own Besins headquarters and the paralllel import of Oestrodose might decrease after Brexit, Oestrogel will be dispensed more frequently. I hope your symptoms are being under control now.

BeaR.
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Jeepers

  • Guest
Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #142 on: November 28, 2019, 09:57:17 PM »

Hi all

Thank you for the replies.

BeaR, I won't be using it again, my symptoms/side effects are horrendous, palpitations are back with a vengeance. I'll stick to the oestrogen , and then see (hope) that everything settles down. I'll feed all of that back to basins and the yellow card scheme, hurdity.

Hi tinker bell, which symptoms flared up? 

Thanks jeepers xx
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Hurdity

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #143 on: January 28, 2020, 10:32:35 PM »

Bumpity bump!

All the info and previous correspondence about oestrogel and oestrodose with Besins is on this thread including information about stability stuides at different temperatures etc  ::)

Some pictures of the bottles were also posted by ex-member Conolly but they have disappeared.

Happy reading folks! Also some of the punctuation has been replaced by weird symbols - must be when the forum was migrated to the new server...

Hurdity x :)
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anneaug

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #144 on: February 01, 2020, 03:05:20 PM »

Hello all, this is my first post here on MM.

Before anything I want to say a MASSIVE thank you to all the posters, and Hurdity in particular, for the posts/advice/knowledge and patience. My HRT journey started 6 weeks ago, despite having been offered it by my GP nine months before then. I feel so much more knowledgeable, reassured and better prepared for what my body might do next  :)

I wanted to add to this Oestrogel/Oestrodose thread, but in no way to contradict what has come before.

My first two gel packs were Oestrogel. All fine. I went to collect my next prescription the other day and was given Oestrodose. I questioned it in the pharmacy and the pharmacist told me it was the French brand name but was exactly the same product, but if I wasn't happy to come back. I felt reassured so came home.

I read the threads here and Hurdity's feedback that Besins said it was the same product, and yes the ingredients appeared to be the same. The order in which the ingredients were listed on original labels on the bottle varied (and I thought in EU countries at least the order was significant?). The other thing was that the Oestrogel contained triethanolamine whereas the Oestrodose contained trolamine. Google is a bit ambiguous but it looks like they are the same thing. But I don't know for sure. Despite my nervousness about trying the Oestrodose I did think it was worth giving it a go. I primed the pump and the consistency seemed to be the same as Oestrogel so again I felt reassured.

Even though I still have a few days worth of Oestrogel in my pump I decided to try the Oestrodose today. Two pumps. It absolutely stank of alcohol in a way that Oestrogel doesn't. And the alcohol smell lingered/tingled as it dried on my arm. I don't normally get that.

Again I decided that I shouldn't let myself be influenced by what might be small variations (I'm an asthmatic and I know that as much I prefer getting Ventolin there are other salbutamol products that work just as effectively...). But I started looking at the labels for the two products to see what was different. The Oestrodose bottle is identical in size, shape and colour scheme to the Oestrogel. The pump seemed the same too.  The only noticeable packaging differences are the box and the label on the pump pack. The UK importer (B&S) had added their own label onto the bottle (which said Oestrogel on the label) and that's when I noticed that the PL numbers on the Oestrogel and Oestrodose were different. The Oestrodose new label says that the product has been repackaged by B&S Healthcare. B&S' website says they: "hold the UK's largest Parallel import licence portfolio, controls bespoke specials manufacturing laboratory, is the country's largest independent distributor of generics"

Oestrogel was PL 28397/0002
Oestrodose was PL 18799/2141

According to Huffington Post and Martin Lewis (and no, neither of these are specialist medical sites, but...) the PL number is an important indicator of what's in the product (https://blog.moneysavingexpert.com/2018/07/martin-lewis--a-drugs-bust-up---stop-letting-big-pharmaceuticals/)

"While the active ingredient is what does the business, there can be other differences, such as how it's delivered. Even then, often inside the packaging, tablets are IDENTICAL - not just the same active ingredient.

On the side of the pack you'll see a product number (or PL number) - this is a unique licence number given exclusively to a particular drug made by a particular manufacturer (eg, PL 12063/0104 is a cold and flu remedy). If two have the same number, they're the exact same product. They have the same active ingredient AND the same formulation."

I took the Oestrodose back to the pharmacy and pointed out that the PL number was different from the Oestrogel, and that even Dr Newsom's website says that some women report that Oestrodose is less effective, and they exchanged them for me.

Surely if the two products were identical, and from the same manufacturer, the PL numbers would be the same? I have pictures of both bottles but don't seem to be able to add them here.

As I said, not trying to challenge what has been said before but genuinely puzzled by all this!

anneaug
« Last Edit: February 01, 2020, 04:28:49 PM by anneaug »
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bear

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #145 on: February 01, 2020, 05:17:55 PM »

Hi anneaug,

Welcome to the forum.  :)

As you can see here...

https://imedi.co.uk/oestrogel-pump-pack#

... all products imported from the EU can have different product licences, depending on where they are sourced by a particular parallel import company. In this case they have a PLPI code number.

https://www.gov.uk/guidance/medicines-apply-for-a-parallel-import-licence

The difference perceived by gel users are real though, IMHO.

Keep us posted!

BeaR
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anneaug

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #146 on: February 01, 2020, 05:36:20 PM »

Thank you BeaR :-)

As I said in my last post, I did notice that the order ingredients were listed were different. My understanding was that ingredients are listed in order of predominance, with the ingredients used in the greatest amount first?

Aside from the active ingredient which I am sure must be the same...

Oestrogel says: carbomer, ethanol, triethanolamine, purified water

Oestrodose says: carbomer, trolamine, ethanol, purified water

I'm not a scientist so I don't know what difference that might make, but it also suggests to me that if the ingredients are listed in a different order that the overall product is not identical!

Anne
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bear

  • Guest
Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #147 on: February 01, 2020, 05:47:47 PM »

Hi again Anne,

Trolamine and Triethanolamine are synonyms.

Have a look at this other thread

https://www.menopausematters.co.uk/forum/index.php/topic,46689.msg752698.html#msg752698

BeaR.
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anneaug

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #148 on: February 01, 2020, 05:55:14 PM »

Hi BeaR

I'd worked that out, thanks. My point in my last post was that the order in which the ingredients are listed is not the same; and that my understanding is that ingredients should be listed in order of predominance?

Anne
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bear

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Re: Oestrogel and Oestrodose - they are exactly the same
« Reply #149 on: February 01, 2020, 06:15:20 PM »

Hi BeaR

I'd worked that out, thanks. My point in my last post was that the order in which the ingredients are listed is not the same; and that my understanding is that ingredients should be listed in order of predominance?

Anne

Sorry, maybe you're right! But I suspect the leaflets provided by parallel import companies may have some minor printing errors?

BeaR

PS. I don't know if the the ingredients have to be listed in order of predominance, but I have checked old leaflets and there is this version as well:

'Excipients: ethanol, carbomer, triethanolamine and purified water'

If this rule really exists, I suspect it could be different in other ( ::)) EU countries and the translation won't be necessary following the UK rule.

https://imedi.co.uk/oestrogel-pump-pack'doc=5
« Last Edit: February 01, 2020, 06:58:44 PM by BeaR »
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