A second 10ft-long python has been rescued close to where another was found just four days earlier.
The latest was spotted on a country lane in Conington, Cambridgeshire, on Monday and the RSPCA urged people to stay vigilant in case there were more.
The charity said it was likely both were either abandoned or escaped from the same place. The first had a minor health condition while the second was "extremely cold" and thin, but both were recovering.
RSPCA Inspector Justin Stubbs said: "It is really concerning to think that someone has kept these pythons, then might have decided to abandon them in this cruel and callous way.
"I only hope that there are no more on the loose."
