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[Katia]

Has anyone tried this new one? Duavive I think it's called Mits for progesterone intolerant women

http://onlinelibrary.wiley.com/store/10.1002/psb.1525/asset/psb1525.pdf;jsessionid=5CCE89DF42E3AA03D12C304FA6DAA892.f02t04?v=1&t=j5osuj4k&s=5cbdddb5b3ecc83f8c7d8471fb5322e8f5822f24

[Butterfly22]

I have read mixed reviews but I thought I'd try it but it wasn't coming up in the computer at the doctors so she said it should in the next three months. I no someone on here has tried it and feels great i ha e seen slot of women saying it's amazing and given them there life back.
Xx

[Katia]

It sounds great. No progesterone. Almost too good to be true.  I'll add it to my list to ask the consultant about st the end of the month

[Scotdownunder]

I started taking duavive 5 weeks ago...the difference is incredible! Although I had no problems with the oestrogens I had tried I was severely progerpsterone intolerant, to the point of it making me suicidal. I was just about to throw in the towel on hrt until the consultant suggested this.

As blood tests have shown for me, at 53 and a positive AMH, I could still have 3-5 years to go to reach full menopause, but at least this has given me some sense of calm and stability back, along with some energy. Hopefully it will help, as I go through this phase as regular scans and possible hysterectomy loom given my reaction to progesterone if I need oestrogen support. Only downside is that it is not funded here so I have to pay about 35GBP per month....but it is worth it for my sanity!

[Mary G]

Scotdownunder, I am so pleased to is working out for you.  Do you have any side effects?

I've just been reading up on Duavive and it sounds very, very interesting.  It seems to be very successful at treating vasomotor symptoms, preventing bone loss and of course the greatest part of all, NO PROGESTERONE. 

I am thinking of giving it a go.  I am currently on the Oestrogel/Utrogestan regime but I'm on borrowed time because I am severely intolerant to all forms of progesterone used in HRT preparations and on a super low dose of Utrogestan.  I realise Duavive is not bio identical but I'm not going to get hung up over that if it works.

Presumably it has been approved in all EU member states so I will try and buy it in Spain. 

[Hurdity]

I'm glad you are doing well on it Scotdownunder. Others will be encouraged by this!

Such a pity though that the oestrogen component in Duavive is the equine oestrogens made from horse urine because this may put off a lot of women - and I can't understand why a product was not developed using estradiol.  From this point of view it's a retrograde step sadly.

For those not already on HRT especially - it's not a good idea to try to buy HRT from other countries without having a medical assessment and prescription.

I can see that it will be very helpful for progesterone intolerant women who are happy with oral HRT and the origin of the oestrogens. I'm wondering why it's not on the website menus yet? Perhaps I'll ask....

Hurdity x

[robotwars]

I have been trying to read up on this but I cant get the link above to work, did anyone else manage to get it to work?

[Hurdity]

No I couldn't either but here is a link to the announcement about its sister drug in US which was released in 2013 - as Duavee:

http://pfizer.newshq.businesswire.com/press-release/pfizer-inc-announces-fda-approval-duavee-conjugated-estrogens-bazedoxifene-treatment-m

Hurdity x

[Scotdownunder]

I must admit I was a little worried when I read some of the information, and it does seem insane that they used old style oestrogen rather than bioidentical. Possibly this was needed to give a difference for the inhibitor, and to differentiate, but that's only a guess,

I have had one visual migraine, probably related to high oestrogen, but have been told not to read too much into the singular high level blood test I had for it, as at this stage my hormones could be doing anything. At least I feel more energetic, less anxious and happy again...and my family are not getting their heads bitten off on a regular basis!

[Butterfly22]

When you have such a nightmare finding HRT I think you get to the point you don't care what you take as long as it helps you, I no that's how I feel anyway.
It's definitely something I'll try if any more HRT problems xx

[Mary G]

Scotdownunder, I agree that it is probably not possible to mix bazedoxifine with bioidentical oestrogen and obviously not in the form of a transdermal gel either.  However, that may be something for the future and could even be in the development stages. 

You mentioned that you had a visual migraine once since starting Duavive, are your migraines triggered by high levels of oestrogen?  The reason I ask is that mine are triggered by all types of progesterone used in HRT preparations - never my own progesterone - and that is why I want to try Duavive.  I also need high levels of oestrogen to feel good and keep the sweats away.

I went to the pharmacy in Spain yesterday and of course it is new here too.  The pharmacist phoned me today and said I can pick it up whenever I like but it costs €35.00 per month which is very expensive and four times the cost of my current regime of Oestrogel/Utrogestan/testosterone and of course the cost of tampons which has to be factored in.  I'm going to give it a go but it will have to be very, very good to justify the expenditure. 

I fear it will not be easy to obtain Duavive via the NHS due to cost and they will probably want people to try loads of other stuff first and only prescribe it as a very last resort.  That said, it will probably be easy to get it on a private prescription.

[Scotdownunder]

Normally it has been hormone change that triggers them eg just before and at the end of my period, i had not had an aura before but it is now thought likely that I possibly ovulated as still in peri. However because of my extreme reaction to progesterone the Consultant thought this was the best way to go.

In NZ it is a private prescription, oestrogen dose is about the equivalent of 37.5 to 50 mg of estradot I was told. I just need a reasonable base line level to function. Brain Fog and inability to talk is the worst and not ideal in my profession - thankfully my consultant recognised the issue having been there! She thinks it is a problem workplaces will have to address as more women are now working in stressful positions at this time in their lives.

Thankfully that does let me fund the Duavive!

[Mary G]

Scotdownunder, thanks for your reply.  I was reading about bazedoxifene and was wondering why it can't be prescribed separately for women with severe progesterone intolerance?  For example, if the oestrogen part of Duavive is the equivalent of a 50 mcg patch or 2 pumps of gel, is it possible to take a 20mg bazedoxifene tablet every day separately?  It's just a thought. 

[Hurdity]

I wonder why it hasn't been suggested for this purpose before now because from what I've read it has been licensed as a drug to treat osteoporosis in Europe (including UK) for some years although not in US. I'm sure there are many women ho might want to try something like this (although would go against my nil-by-mouth approach to HRT!) - and obviously depending on what the long term risks are that are known about. It is only for use in post-menopausal women.

Hurdity x

[Mary G]

I had a long consultation yesterday in my usual pharmacy in Spain and after much discussion, I have decided to try a Bazedoxifine and Oestrogel combination - in other words, Duavive with bio identical oestrogen instead of conjugated oestrogen.  Having sought medical advice, there is no reason why I can't use this combination so I am prepared to take the risk and give it a try.  I'm not getting my hopes up because it might not work but in my situation, anything has to be worth a try, within reason of course.  I have regular uterine scans so I can chart my progress.

There is definitely some connection between womb lining shedding and migraines in my case so I am hoping that bazedoxifine will prevent this from happening. 

I think bazedoxifine could be what all progesterone intolerant women have been waiting for and perhaps it will turn out to be the womb disabler that I have been banging on about on here.  It is early days but I am encouraged by the fact that it directs oestrogen away from the womb receptors and breasts and directs it to where it is needed which is why it is used for osteoporosis prevention and it going to be used for oestrogen positive breast cancer patients.  My thinking is why use progesterone which makes me semi-loopy and causes heavy periods when I can take something that makes my oestrogen work better - hopefully. 

Both Duavive and Bazedoxifine (same manufacturer) are expensive and cost exactly the same i.e. €34.41.  This is probably deliberate because the drug company knows that people will use it separately. 

Katia, thank you so much for starting this thread and sorry to hijack it. I will be starting my new regime in a few weeks after my next Utrogestan phase and will start a new threat after that. 

Sorry, I meant to add, this regime is only suitable for post menopausal women who are progesterone intolerant.