HI there, I was Kliofem 2mg/1mg for 9years. In January 2018 I developed, overnight, acute anxiety and depression. My GP offered diazapham and citalopram. I had never experienced any of these before. I have what some would say is a stressful job but I didn't find it stressful but accepted that I must have burned out. I didn't take the diazapham and the citalopram didn't seem to work. I contacted a menopause Doctor who said that she thought my receptors to Kilofem had stopped working (after doing the Greene Climacteric Scale assessment on me) and moved me on Transderman Everol Conti patches. I am 2 weeks on these and they seem to be significantly helping. I think the estradiol level is the same it is just that my body is getting this through the skin as opposed to orally which says to me that it is not the estradiol that is the problem but the manner in which your body gets it. I hope don't confuse the issue and it is early days for me yet but there must be something in the differant way the HRT is received i.e. by skin or mouth.