My prescription for is estradiol 50mcg, so I get what I'm given! And they rarely have them in my nearest pharmacy. They have to order them in, usually arriving the next day. From the benefit point of view, I can't say I notice any difference, but I prefer estrodot. I'm wearing a make now that I have never seen before ( Estraderm) and don't like as it does not adhere very well, as it is like cellophane and too stiff.