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[jasper]

Thanks for the link Hurdity. Is there any rationale as to why progesterone might cause worse muscle / neck / shoulder pain?

[jasper]

I stopped the Zoely on Friday as the muscle pain (neck, legs, back) was unbearable. It maybe it isn't the Zoely causing it (wondering if it could be making my borderline hypothyroid worse) but I figure this is the only way to find out? Stuck a 50 evorel on to try to reduce the crash from stopping it.

Anyone know how soon side effects (if this is what it is) would disappear? If it wasn't the Zoely then I'm in real trouble 😪
Thanks

[Hurdity]

Sorry I can't help re the side effects of Zoely but there is definitely the potential for interaction between thyroid meds (for underactive thyroid) and oral oestrogen - the technical aspects of which escape me at the moment, but mean that those taking medication may need to have their medication reviewed after starting oral HRT. It could well be that there is a similar interaction even for those not taking medication for borderline under-active thyroid. I quoted from a study about this recently - just had a search and here is the extract:

"Because of its hepatic first-pass effect, oral estrogen therapy, the most commonly used modality of ET/HT, raises the circulating levels of thyroxine-binding globulin (TBG), thereby increasing the bound fraction and decreasing the free (bioactive) fraction of circulating thyroxine (T(4))"
Here is the thread where I quoted this:
http://www.menopausematters.co.uk/forum/index.php/topic,30662.msg487889.html#msg487889

Muscle pain is a feature of underactive thyroid so it could well be a secondary response to the therapy in view of your hormone levels. Depending on how borderline you are I would see if you can get some low dose treatment for this or at least ask to be referred because you have a better chance of the HRT working if your thyroid function is good. Someone started a thread about this recently  (ie thryoid function and HRT) referring to women who have had ovaries removed but the arguments still apply to everyone I think.

I don't think stopping it will tell you if it is the tablet (oral oestrogen) is affecting your thyroid function - as you say it could also be the progestogen not agreeing with you.

Hurdity  x