Oh yes! Mine started when I was approximately one year into peri and developed a urinary tract infection. I went to out of hours GP as it was excruciating, and the GP prescribed Trimethoprim. I'd had this antibiotic before a few times with no problems.
We had to drive to a late night pharmacy and the GP had told me to get a dose in asap, so I took one tablet in the car with bottled water. As soon as I swallowed it, my throat felt kinda lumpy, but then it went. We drove home and 5 minutes into our journey, I started to feel really agitated. 5 more minutes and my palms felt a bit itchy. Got home, dashed into house to run itching palms under the tap in the bathroom and looked in the mirror and my lips were purple tinged. And then I started sweating profusely. I remember looking at my hands and the just kind of bubbled with what looked like huge blisters. And then I got the terrifying feeling of sheer terror. I literally screamed for my Husband who was downstairs, and then everything went orangey black in my vision and I felt as if I was going to lose control of my bowels. Hubby grabbed the phone and dialled 999, and I was croaking very loudly 'in gonna die!' as my throat was getting very lumpy again.
Luckily I live just 5 minutes from the hospital and the ambulance arrived. I was in anaphylactic shock. They had to inject adrenaline and start a steroid infusion as well as supportive fluids. I stabilised and was helped down to the ambulance with Hubby to follow in the car. On the way to the hospital, I had a biphasic reaction and they had to repeat the treatment. They had to stop the ambulance on the way.
When we got to hospital, Hubby was ashen faced as he'd been waiting and went a different route and expected the ambulance to have arrived before him. I had to stay in over night, and thus began my nightmare of becoming allergic all of a sudden to multiple unrelated medications. I carry 2 epi pens with me everywhere now.
All of this was out of the blue, I never had a problem before this episode.
Needless to say, I'm now terrified of getting unwell for any reason in case I need medication. It's been a total nightmare so I am constantly in a state of health anxiety. It also doesn't help that doctor's are scared witless to treat you when they know you've had multiple life threatening drug allergies!