Hi. I looked at some of your other posts and it looks like you are one of the unlucky super-sensitive ones. I can't say how long it will last, I haven't had any breast soreness with estrogen. The headaches come and go for me but I haven't yet been able to pin them to hrt. Maybe you're in an upsurge of your own hormones? Is that possible or are you still under treatment to shut down your ovaries? I am on the US version of estrodot, and I'm not sure I could trim any off the 50 without making it smaller than the 37.5. They are so close in size, maybe you're actually getting less estrogen than before?