Well, I would think so, at first anyway. Make sure you get settled on the vagifem for a couple of months first though.
If you want to reduce the others, then you could try a little at a time. Vagifem might be enough for you, but I need Vagifem and systemic.
Be sure to discuss this with your doctor.
Everytime I have tried to stop the systemic HRT and just use vagifem, I am fine for a few (3-4) months and then the VA feeling comes back, even using vagifem 2x or 3x a week. Its not the hot flashes that make me go back to the systemic HRT on top of the vagifem, it is the constant vaginal and bladder pain/irritation.