My GP gave me Gynest cream made by Marlborough Pharmaceuticals for external use alongside Vagifem and it worked well. I used it once or twice a week. This has now been changed to generic Estriol cream made also by MP and in an almost identical tube but something must have changed or why alter it. Since using this new cream I get slight soreness and little tiny pimply spots where I apply it. Cheaper ingredients? Anyone else experience with this?