Sphere27, Oh dear, how disappointing for you. One of the side effects of progesterone (Utrogestan - see the side-effects list on the leaflet) is depression. Progesterone is known to make us feel calm/flat. Maybe you just don't get on with this form of progesterone. As you say, one month isn't long, but when you feel so low the thought of waiting to see if things improve isn't attractive. I recently stopped HRT altogether because of low or erratic moods and feeling demotivated and unable to get up in the morning and I feel much more stable and motivated. I suppose you've got 4 choices - stick with it; go back to your GP; stop the HRT altogether; stop the Utrogestan for a while and see if your mood improves (though this might bring on a bleed). In your shoes I'd do the latter. Others will probably have advice for you too, most problems brought to this forum have been experienced by someone else! Hope you feel better soon.