Does anyone have any experience with taking progesterone cream? I am having terrible problems waking up every morning after 5 a.m. either being hot or sweating but always with anxiety. I am in post meno and estrogen and progesterone levels are very low. Everyday I wake up with anxiety. My Dr. has me taking 50mg of progesterone 3 times a day. Said that will help with the adrenaline surges and anxiety I am having. After 2 1/2 weeks of doing this I have seen no change at all. I am miserable and most days don't function well. I have always taken good care of myself through diet, exercise, and spiritually. This has been by far the worst period of time of this menopause journey. Can someone please comment on any of this. I'm emotionally exhausted as I once was a very active vibrant person. This has really grounded me. I am trying to tell myself that this is all hormone related. Will call my Dr. today to discuss the progesterone.